ArticleParasites & vectors2020
Multiple insecticide resistance target sites in adult field strains of An. gambiae (s.l.) from southeastern Senegal.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Mechanisms of carbamate resistance in the malaria vector:Parasite epidemiology and control · 2026Review
- Genetic divergence and lower frequencies of insecticide resistance markers in the novel Anopheles gambiae Bissau molecular form in The Gambia.Scientific reports · 2026Article
- Residual efficacy of indoor residual spraying using clothianidin (SumiShield 50WG) under experimental huts and field conditions in Senegal.Malaria journal · 2026Article
- The impacts of indoor residual spraying with bendiocarb and pirimiphos-methyl on allelic frequencies of kdr and ace-1 mutations in central Senegal.Scientific reports · 2025Article
- Factors Associated WithJournal of parasitology research · 2025Article
- The P450-Monooxygenase Activity and CYP6D1 Expression in the Chlorfenapyr-Resistant Strain ofInsects · 2024Article
- Differential insecticide resistance inHeliyon · 2023Article
- Insecticide susceptibility status in two medically important mosquito vectorsSaudi journal of biological sciences · 2023Article
- Evolution of thePathogens (Basel, Switzerland) · 2022Article
- Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of theGenes · 2021Article
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9 authors.
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Abstract
backgroundHigh coverage of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the cornerstones of vector control strategy in Senegal where insecticide resistance by the target vectors species is a great of concern. This study explores insecticide susceptibility profile and target-site mutations mechanisms within the Anopheles gambiae complex in southeastern Senegal.
methodsLarvae of Anopheles spp. were collected in two sites from southeastern Senegal Kedougou and Wassadou/Badi in October and November 2014, and reared until adult emergence. Wild F
resultsA total of 3742 An. gambiae (s.l.) were exposed to insecticides (2439 from Kedougou and 1303 from Wassadou-Badi). Tests with pyrethroid insecticides and DDT showed high level of resistance in both Kedougou and Wassadou/Badi. Resistance to pirimiphos-methyl and malathion was not detected while resistance to bendoicarb and fenitrothion was confirmed in Kedougou. Of the 745 specimens of An. gambiae (s.l.) genotyped, An. gambiae (s.s.) (71.6%) was the predominant species, followed by An. arabiensis (21.7%), An. coluzzii (6.3%) and hybrids (An. gambiae (s.s.)/An. coluzzii; 0.4%). All target site mutations investigated (Vgsc-1014F, Vgsc-1014S, Ace-1 and Rdl) were found at different frequencies in the species of the Anopheles gambiae complex. Vgsc-1014F mutation was more frequent in An. gambiae (s.s.) and An. coluzzii than An. arabiensis. Vgsc-1014S was present in An. gambiae (s.l.) populations in Wassadou but not in Kedougou. Ace-1 and rdl mutations were more frequent in An. gambiae (s.s.) in comparison to An. arabiensis and An. coluzzii.
conclusionsResistance to all the four insecticide classes tested was detected in southeastern Senegal as well as all target site mutations investigated were found. Data will be used by the national Malaria Control Programme.
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