Evidence map›Paper›PMID 33176796›Full record

Trial reportJournal of the International Society of Sports Nutrition2020

The effect of vitamin D supplementation on the muscle damage after eccentric exercise in young men: a randomized, control trial.

W Pilch, B Kita, A Piotrowska, Ł Tota, M Maciejczyk, O Czerwińska-Ledwig, E Sadowska-Krepa, S Kita, T Pałka

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

W PilchInstitute for Basics Sciences, Faculty of Rehabilitation, University of Physical Education, Krakow, Poland.ORCID https://orcid.org/0000-0001-6689-0155
B KitaFaculty of Physical Activity and Sport, University of Physical Education, Krakow, Poland.
A PiotrowskaInstitute for Basics Sciences, Faculty of Rehabilitation, University of Physical Education, Krakow, Poland. anna.piotrowska@awf.krakow.pl.ORCID https://orcid.org/0000-0002-9535-173X
Ł TotaInstitute for Biomedical Sciences, Faculty of Physical Activity and Sport, University of Physical Education, Krakow, Poland.ORCID https://orcid.org/0000-0001-7108-0704
M MaciejczykInstitute for Biomedical Sciences, Faculty of Physical Activity and Sport, University of Physical Education, Krakow, Poland.ORCID https://orcid.org/0000-0002-9505-4081
O Czerwińska-LedwigInstitute for Basics Sciences, Faculty of Rehabilitation, University of Physical Education, Krakow, Poland.ORCID https://orcid.org/0000-0003-1855-1276
E Sadowska-KrepaInstitute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.ORCID https://orcid.org/0000-0002-9374-8071
S KitaInstitute for Biomedical Sciences, Faculty of Physical Activity and Sport, University of Physical Education, Krakow, Poland.
T PałkaInstitute for Biomedical Sciences, Faculty of Physical Activity and Sport, University of Physical Education, Krakow, Poland.ORCID https://orcid.org/0000-0001-5225-9397
University School of Physical Education in Kraków · PLAkademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach · PL

Funding

Narodowe Centrum Nauki 74/MN/INB/2015
6 · The paper itself

Abstract

backgroundVitamin D contributes to the optimal functioning of muscles. This study was designed to determine the modulating effect of vitamin D supplementation on the degree of muscle cell damage caused by eccentric exercise in young men.

methods60 male volunteers (20-24 years old) taking part in this study were divided in two groups - with suboptimal (S) and optimal (O;) 25(OH)D plasma levels. These groups were randomly subdivided into groups with vitamin D supplementation (experimental: SE and OE) and controls (SC and OC). Before the supplementation (Test I) and after 3 months (Test II), participants were subjected to two rounds of eccentric exercise tests on a declined treadmill (running speed corresponded 60% VO2peak determined in each subject in incremental exercise test). During each test, blood samples used for determination of 25(OH)D, Il-1β, myoglobin (Mb) levels and CK, LDH activity were taken at three timepoints: before the test, 1 h and 24 h after it ended. After distribution normality testing (Saphiro-Wilk test), statistical analyses were performed. Non-parametric: Kruskal-Wallis test and the Wilcoxon test were applied, and the Dunn-Bonferroni test as a post-hoc test.

resultsIn all groups, after 3 months, higher concentrations of 25(OH)D were indicated (SE p = 0.005; SC p = 0.018; OE p = 0.018; OC p = 0.028). SE and SC groups showed higher baseline concentrations of Il-1β and significantly higher concentrations of this interleukin after 1 h compared to groups with an optimal 25(OH)D level. After supplementation, the SE group reacted with a similar jump in concentration of Il-1β as the OC and OE groups. The change after 1 h after exercise in Test II was significantly different from that from Test I (p = 0.047) in SE group. Lower Mb concentrations indicated 1 h after exercise in Test II for SC and SE groups were indicated. CK activity did not differentiate the studied groups. Plasma calcium and phosphate disorders were also not indicated.

conclusionsThe study has shown that vitamin D doses determined from the plasma concentration of 25(OH)D of individuals to match their specific needs can significantly reduce muscle cell damage induced by eccentric exercise.

Indexed as

Dietary Supplements25-Hydroxyvitamin D 2Body Mass IndexCalciumCreatine KinaseExerciseExercise TestHumansHydro-LyasesInterleukin-1betaMaleMuscle Fibers, SkeletalMyoglobinPhosphatesVitamin DYoung Adult25-Hydroxyvitamin D 2CalciumCreatine KinaseHydro-LyasesInterleukin-1betalactate dehydrataseMyoglobinPhosphatesVitamin DCKEccentric exerciseIl-1βLDHMuscle cell damageMyoglobinVitamin D

Identifiers

PMID33176796
PMCPMC7661179
OpenAlexW3100902416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.