ArticleBMC veterinary research2020
Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.
Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Haemorrhagic myelopathy causing acute post-operative paralysis in a rabbit (Oryctolagus cuniculus) with a congenital lordosis.The Journal of small animal practice · 2026Article
- Subcutaneous Buprenorphine Is an Acceptable Preoperative Analgesic in Pregnant Ewes Undergoing Hysterotomy (Ovis aries).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Assessment of Opioid Analgesia in New Zealand White Rabbits (Oryctolagus cuniculus) Using Thermal Threshold Testing.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery.Animals : an open access journal from MDPI · 2025Article
- Exosomal miR‑194 from adipose‑derived stem cells impedes hypertrophic scar formation through targeting TGF‑β1.Molecular medicine reports · 2024Article
- Pharmacokinetics of dexmedetomidine in anaesthetized horses following repeated subcutaneous administration and intravenous constant rate infusion.BMC veterinary research · 2023Article
- Pharmacokinetics and Pharmacodynamics of Butorphanol and Dexmedetomidine after Intranasal Administration in Broiler Chickens (Veterinary sciences · 2022Article
- Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.BMC veterinary research · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBuprenorphine is one of the most used analgesics for postoperative pain in rabbits. The recommended dose in rabbits (0.01-0.05 mg/kg) is the same for intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration, despite lack of pharmacokinetic data. Five male and five female New Zealand White rabbits (mean ± SD body weight 3.1 ± 0.3 kg) were administered 0.05 mg/kg buprenorphine by the IV, IM and SC routes and 0.1 mg/kg by the SC route, in a cross-over design with two-week wash-out periods between treatments. Blood was collected before, and up to 8 h post buprenorphine injection, for determination of serum levels by UPHLC-MS/MS.
resultsThe area under the time concentration curve (AUC
conclusionsThe lower bioavailability of 0.05 mg/kg buprenorphine after SC administration could explain the lack of efficacy seen in clinical pain studies in rabbits, using this route. For immediate pain relief, IV or IM administration is therefore be recommended, whereas SC administration may be useful to sustain analgesic serum levels, once efficient pain relief has been achieved. The current data do not support an increase in dose to compensate for the lower SC bioavailability.
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Registered trials
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