ArticleBrain : a journal of neurology2020
Disentangling vulnerability, state and trait features of neurocognitive impairments in depression.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Change in Cognitive Function over the Course of Major Depressive Disorder: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study.JMIR research protocols · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- No Cognitive Scarring Over 20 Years in Recurrent Depression: Bidirectionality of Cognitive Functioning and Depression.Clinical psychology in Europe · 2026Article
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Article
- Exploring Task Design and Heuristics Interaction Through a Knowledge-Free Option Generation Task.Scandinavian journal of psychology · 2025Article
- Multivariate patterns among multimodal neuroimaging and clinical, cognitive, and daily functioning characteristics in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The Pathway Relationship Between Physical Activity Levels and Depressive Symptoms in University Students Mediated by Cognitive Flexibility.Brain and behavior · 2025Article
- Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Depression and anxiety in peruvian military personnel during the pandemic context: a cross-sectional study.BMC public health · 2023Article
- Explainable machine learning approach to predict and explain the relationship between task-based fMRI and individual differences in cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Validating the Children's Depression Inventory-2: Results from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study.PloS one · 2023Article
- Functional connectivity analysis of childhood depressive symptoms.NeuroImage. Clinical · 2023Article
- Longitudinally stable, brain-based predictive models mediate the relationships between childhood cognition and socio-demographic, psychological and genetic factors.Human brain mapping · 2022Article
- Multiple-Network Alterations in Major Depressive Disorder With Gastrointestinal Symptoms at Rest Revealed by Global Functional Connectivity Analysis.Frontiers in neuroscience · 2022Article
- Does cognitive behaviour therapy affect peripheral inflammation of depression? A protocol for the systematic review and meta-analysis.BMJ open · 2021Article
- Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Minding the Gap: Adolescent and Parent/Caregiver Reporter Discrepancies on Symptom Presence, Impact of Covariates, and Clinical Implications.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Depression is a debilitating disorder that often starts manifesting in early childhood and peaks in onset during adolescence. Neurocognitive impairments have emerged as clinically important characteristics of depression, but it remains controversial which domains specifically index pre-existing vulnerability, state-related or trait-related markers. Here, we disentangled these effects by analysing the Adolescent Brain Cognitive Development dataset (n = 4626). Using information of participants' current and past mental disorders, as well as family mental health history, we identified low-risk healthy (n = 2100), high-risk healthy (n = 2023), remitted depressed (n = 401) and currently depressed children (n = 102). Factor analysis of 11 cognitive variables was performed to elucidate latent structure and canonical correlation analyses conducted to probe regional brain volumes reliably associated with the cognitive factors. Bayesian model comparison of various a priori hypotheses differing in how low-risk healthy, high-risk healthy, remitted depressed and currently depressed children performed in various cognitive domains was performed. Factor analysis revealed three domains: language and reasoning, cognitive flexibility and memory recall. Deficits in language and reasoning ability, as well as in volumes of associated regions such as the middle temporal and superior frontal gyrus, represented state- and trait-related markers of depression but not pre-existing vulnerability. In contrast, there was no compelling evidence of impairments in other domains. These findings-although cross-sectional and specific to 9-10-year-old children-might have important clinical implications, suggesting that cognitive dysfunction may not be useful targets of preventive interventions. Depressed patients, even after remission, might also benefit from less commonly used treatments such as cognitive remediation therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.