ArticleNature2021
Decoding myofibroblast origins in human kidney fibrosis.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 496 papers.
0numbers the graph read from it
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496citing papers in PubMed
30.8field-weighted citation impact, top 1% of its field
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Who cites it
496 citing papers in PubMed, 705 citations in OpenAlex.
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- Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease.Renal failure · 2026Article
- Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15.Renal failure · 2026Article
- Mitochondrial dysfunction of renal tubular epithelial cells in chronic kidney disease-associated fibrosis: from organelle homeostasis to multicellular remodeling.Molecular biology reports · 2026Review
- Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.Nature biomedical engineering · 2026Article
- Integrated bioinformatics analysis and clinical validation identifies TNFSF14 and CD40 as novel biomarkers for chronic kidney disease progression and tubulointerstitial injury.International urology and nephrology · 2026Article
- Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte-Mediated Fibrosis and Protecting Nucleus Pulposus Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell RNA Sequencing Analysis Reveals That Targeting PLG-PLGRKT Signaling-mediated Pro-fibrotic Scar-associated Macrophages Ameliorates Liver Fibrosis in Biliary Atresia.Journal of clinical and translational hepatology · 2026Article
- T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The role of senescence in kidney ageing, injury and fibrosis.Nature reviews. Nephrology · 2026Review
- Macrophage-Fibroblast Crosstalk in Kidney Injury: A Narrative Review.International journal of molecular sciences · 2026Review
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Pericyte-myofibroblast transition: a novel mechanism in peritoneal fibrosis and the effect of Asiaticoside.Journal of advanced research · 2026Article
- Transforming growth factor-β in kidney disease in dogs and cats: a review of the evidence of its role in renal fibrosis.Journal of veterinary internal medicine · 2026Review
- Review
- The Lactate-lactylation circuitry in kidney fibrosis: cellular crosstalk from tubular metabolic reprogramming to macrophage effector functions.Seminars in immunopathology · 2026Review
- Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?Life (Basel, Switzerland) · 2026Article
- Matrix Gla Protein is a novel regulator of TGFβ-dependent fibroblast activation and kidney fibrosis.Molecular biomedicine · 2026Article
- Interferon-λ drives renal fibrosis by coordinating epithelial-fibroblast crosstalk.The Journal of experimental medicine · 2026Article
- Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review).International journal of molecular medicine · 2026Review
436 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 9 institutions in 5 countries.
Christoph Kuppe *Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-4597-9833
Mahmoud M Ibrahim *Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-6954-5314
Jennifer KranzInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Xiaoting ZhangInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Susanne ZieglerInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Javier Perales-PatónInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-0780-6683
Jitske JansenInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Katharina C ReimerDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-7118-9133
James R SmithCentre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Ross DobieCentre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
John R Wilson-KanamoriCentre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1372-9912
Maurice HalderDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-2386-9684
Yaoxian XuInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Nazanin KabganiInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Nadine KaeslerDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Martin KlausIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-0880-3302
Lukas GernholdIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Victor G PuellesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7735-5462
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter BoorDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-9921-4284
Sylvia MenzelInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Remco M HoogenboezemDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Eric M J BindelsDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Joachim SteffensDepartment of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany.
Jürgen FloegeDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Rebekka K SchneiderDepartment of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany.
Julio Saez-RodriguezInstitute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8552-8976
Neil C HendersonCentre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2273-4094
Rafael KramannDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.ORCID http://orcid.org/0000-0003-4048-6351
RWTH Aachen University · DECentre for Inflammation Research · GBUniversität Hamburg · DEErasmus MC Cancer Institute · NLHeidelberg University · DESankt-Antonius-Hospital Eschweiler · DEBayer (Germany) · DEErasmus MC · NLRadboud University Nijmegen · NL
Funding
European Research Council 677448Medical Research CouncilWellcome TrustWellcome Trust 104366/Z/14/ZWellcome Trust 219542/Z/19/Z
Abstract
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist
Indexed as
Cell LineageAdaptor Proteins, Signal TransducingAnimalsCalcium-Binding ProteinsCase-Control StudiesCell DifferentiationExtracellular MatrixFemaleFibroblastsFibrosisHumansKidney TubulesMaleMesodermMiceMyofibroblastsAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsNKD2 protein, humanReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.