Evidence map›Paper›PMID 33176188›Full record

ArticleNeuroscience2021

Ring Finger Protein 11 (RNF11) Modulates Dopamine Release in Drosophila.

Eve Privman Champaloux, Nathan Donelson, Poojan Pyakurel, Danielle Wolin, Leah Ostendorf, Madelaine Denno, Ryan Borman, Chris Burke, Jonah C Short-Miller, Maria R Yoder and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. ACS chemical neuroscience · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Eve Privman ChampalouxNeuroscience Graduate Program and Medical Scientist Training Program, University of Virginia, Charlottesville, VA, United States.
Nathan DonelsonBiogen-Idec, Cambridge, MA, United States.
Poojan PyakurelDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States.
Danielle WolinDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States.
Leah OstendorfDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States.
Madelaine DennoDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States.
Ryan BormanDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States.
Chris BurkeBiogen-Idec, Cambridge, MA, United States.
Jonah C Short-MillerDepartment of Biology, Eastern Mennonite University, Harrisonburg, VA, United States.
Maria R YoderDepartment of Biology, Eastern Mennonite University, Harrisonburg, VA, United States.
Jeffrey M CopelandDepartment of Chemistry, University of Virginia, Charlottesville, VA, United States; Department of Biology, Eastern Mennonite University, Harrisonburg, VA, United States.
Subhabrata SanyalBiogen-Idec, Cambridge, MA, United States.
B Jill VentonNeuroscience Graduate Program and Medical Scientist Training Program, University of Virginia, Charlottesville, VA, United States; Department of Chemistry, University of Virginia, Charlottesville, VA, United States. Electronic address: jventon@virginia.edu.
University of Virginia · USBiogen (United States) · USEastern Mennonite University · US

Funding

Real-Time Measurements of Neurotransmission in Drosphilia melanogasterR01MH085159 · NIMH · UNIVERSITY OF VIRGINIA · PI B. JILL VENTON · 2009 to 2026
$5.9M
NIMH NIH HHS R01 MH085159
6 · The paper itself

Abstract

Recent work indicates a role for RING finger protein 11 (RNF11) in Parkinson disease (PD) pathology, which involves the loss of dopaminergic neurons. However, the role of RNF11 in regulating dopamine neurotransmission has not been studied. In this work, we tested the effect of RNF11 RNAi knockdown or overexpression on stimulated dopamine release in the larval Drosophila central nervous system. Dopamine release was stimulated using optogenetics and monitored in real-time using fast-scan cyclic voltammetry at an electrode implanted in an isolated ventral nerve cord. RNF11 knockdown doubled dopamine release, but there was no decrease in dopamine from RNF11 overexpression. RNF11 knockdown did not significantly increase stimulated serotonin or octopamine release, indicating the effect is dopamine specific. Dopamine clearance was also changed, as RNF11 RNAi flies had a higher V

Indexed as

DopamineDrosophilaAnimalsCentral Nervous SystemDNA-Binding ProteinsDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsDrosophila ProteinsHumansSerotoninDNA-Binding ProteinsDopamineDopamine Plasma Membrane Transport ProteinsDrosophila ProteinsRNF11 protein, humanSerotonindopaminedopamine transporterDrosophilaParkinson diseaseRNF11voltammetry

Identifiers

PMID33176188
PMCPMC7769989
OpenAlexW3103548011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.