ArticleCell reports2020
Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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53citing papers in PubMed, 2 pooled it
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury.Human brain mapping · 2025Pooled it
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Cellular source and circuit context organize functional specificity in thebioRxiv : the preprint server for biology · 2026Article
- Dual regulatory mechanisms of the ZI-LHb circuit in SPS&S model mice: dissociable control of aversion and anxiety through distinct downstream targets.Molecular psychiatry · 2026Article
- Drug self-administration in head-fixed mice.Nature protocols · 2026Review
- Extended amygdala orchestrates social motivation in socially isolated mice.bioRxiv : the preprint server for biology · 2026Article
- Beyond Fear Learning in Isolation: Integration of Social Dimensions into Aversive Learning.Current protocols · 2026Review
- Biased signaling at NTSR1 differentially regulates inhibitory synaptic transmission in the extended amygdala and suppresses motivated feeding in mice.bioRxiv : the preprint server for biology · 2026Article
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Resting-state EEG alpha-BOLD coupling spatially follows cortical cell-type and receptor gradients.bioRxiv : the preprint server for biology · 2026Article
- Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis modulate avoidance behaviors and feeding.Frontiers in neuroscience · 2026Article
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- The Bed Nucleus of the Stria Terminalis-Deep Mesencephalic Nucleus Circuit Linking Emotion and Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
- Prepronociceptin-Expressing Neurons in the Bed Nucleus of the Stria Terminalis Signal Escape Behavior.Biological psychiatry global open science · 2025Article
- Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes.Bone research · 2025Article
- Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway.Nature communications · 2025Article
- Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system.Cell reports · 2025Article
- A cell-type-specific circuit of somatostatin neurons in the habenula encodes antidepressant action in male mice.Nature communications · 2025Article
- Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025Review
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Authors and funding
16 authors at 3 institutions in 1 country.
Jose Rodriguez-RomagueraDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Randall L UngNeuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, NC 72599, USA.
Hiroshi NomuraDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
James M OtisDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Marcus L BasiriNeuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, NC 72599, USA.
Vijay M K NamboodiriDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Xueqi ZhuDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
J Elliott RobinsonNeuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, NC 72599, USA.
Hanna E van den MunkhofDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Jenna A McHenryDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Louisa E H EckmanDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Oksana KosykDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA.
Thomas C JhouDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
Thomas L KashNeuroscience Curriculum, University of North Carolina, Chapel Hill, NC 72599, USA; Bowles Center for Alcohol Studies, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 72599, USA.
Michael R BruchasDepartment of Anesthesiology, Washington University Pain Center, Department of Neuroscience, Division of Biology & Biomedical Sciences; and Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
Garret D StuberDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 72599, USA; Neuroscience Curriculum, University of North Carolina, Chapel Hill, NC 72599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 72599, USA. Electronic address: gstuber@uw.edu.
University of North Carolina at Chapel Hill · USMedical University of South Carolina · USWashington University in St. Louis · US
Funding
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0MUNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5MRESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0MDecoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3MNeural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5MLateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0MPostdoctoral Training in Reproductive Mood DisordersT32MH093315 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN Scott GIRDLER, David R. Rubinow · 2012 to 2026
$2.8MSleep, opiate withdrawal and the N/OFQ - NOP systemR01HL150836 · NHLBI · SRI INTERNATIONAL · PI BRUCHAS, MICHAEL R., KILDUFF, THOMAS S · 2019 to 2019
$2.0MNeural encoding of associative learning by orbitofrontal cortex circuitsR00MH118422 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI K NAMBOODIRI, VIJAY MOHAN · 2020 to 2022
$747kEvaluating the function and activity dynamics of thalamic inputs for reward seeking and consumptionF32DA041184 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OTIS, JAMES M · 2016 to 2018
$144kNeural encoding of associative learning by orbitofrontal cortex circuitsK99MH118422 · NIMH · UNIVERSITY OF WASHINGTON · PI K NAMBOODIRI, VIJAY MOHAN · 2019 to 2020
$141kFunctional dynamics of BNST neurons during distinct anxiety statesF32MH113327 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RODRIGUEZ-ROMAGUERA, JOSE · 2017 to 2019
$128kNHLBI NIH HHS R01 HL150836NIDA NIH HHS F32 DA041184NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA038168NIDA NIH HHS R37 DA032750NIMH NIH HHS F30 MH115693NIMH NIH HHS F32 MH113327NIMH NIH HHS K99 MH115165NIMH NIH HHS K99 MH118422NIMH NIH HHS R00 MH118422NIMH NIH HHS R01 MH112355NIMH NIH HHS T32 MH093315NINDS NIH HHS P30 NS045892NINDS NIH HHS T32 NS007431
Abstract
Motivational states consist of cognitive, emotional, and physiological components controlled by multiple brain regions. An integral component of this neural circuitry is the bed nucleus of the stria terminalis (BNST). Here, we identify that neurons within BNST that express the gene prepronociceptin (Pnoc
Indexed as
AmygdalaAnimalsArousalBehavior, AnimalMaleMiceNeuronsProtein PrecursorsReceptors, OpioidprepronociceptinProtein PrecursorsReceptors, Opioidand pupillometryanxiety-like behavioraversionBNSThyperarousalreward
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.