ArticlePloS one2020
Urine metabolomics of rats with chronic atrophic gastritis.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Renqing Mangjue modulates chronic atrophic gastritis inflammation-cancer transition via the cGMP-PKG/PI3K-AKT pathway.Chinese medicine · 2026Article
- Article
- Changes of gastric microflora and metabolites in patients with chronic atrophic gastritis.Journal of translational medicine · 2025Article
- Single-cell transcriptomic data reveal the cellular heterogeneity of glutamine metabolism in gastric premalignant lesions and early gastric cancer.Acta biochimica et biophysica Sinica · 2025Article
- The metabolites mainly composed of lipids in tongue coating are non-invasive potential biomarkers for chronic gastritis.Scientific reports · 2024Article
- Quantification of 11 metabolites in rat urine after exposure to organophosphates.Laboratory animal research · 2024Article
- Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.Journal of inflammation research · 2024Article
- Identification of the Biomarkers for Chronic Gastritis with TCM Damp Phlegm Pattern by Using Tongue Coating Metabolomics.Journal of inflammation research · 2024Article
- High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis.Biomedicines · 2023Article
- The dysregulation of unsaturated fatty acid-based metabolomics in the MNNG-induced malignant transformation of Het-1A cells.Environmental science and pollution research international · 2022Article
- Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis.Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
9 authors.
Funding
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Abstract
BACKGROUND/
aimTo use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). MATERIALS AND
methodsMethylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method.
resultsCompared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism.
conclusionBy searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.
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