Evidence map›Paper›PMID 33175676›Full record

ArticleIEEE transactions on bio-medical engineering2021

Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.

Ruofei Bu, Santosh Balakrishnan, Nicusor Iftimia, Hillel Price, Carlton Zdanski, Sorin Mitran, Amy L Oldenburg

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  2. Article
  3. Journal of biomedical optics · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruofei Bu
Santosh Balakrishnan
Nicusor Iftimia
Hillel Price
Carlton Zdanski
Sorin Mitran
Amy L Oldenburg

Funding

Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure MeasurementR01HL154429 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L, ZDANSKI, CARLTON J · 2020 to 2024
$4.0M
Anatomic optical coherence tomography for quantitative bronchoscopyR01HL123557 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L, ZDANSKI, CARLTON J · 2015 to 2017
$1.9M
Imaging nanophysical properties of actively transporting bronchial mucusR21HL130901 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2016 to 2017
$418k
Development of a method for in situ nanorheology of human airway mucusR21HL111968 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2012 to 2013
$392k
Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury ManagementR43HL154866 · NHLBI · PHYSICAL SCIENCES, INC · PI IFTIMIA, NICUSOR · 2020 to 2020
$259k
NHLBI NIH HHS R01 HL123557NHLBI NIH HHS R01 HL154429NHLBI NIH HHS R21 HL111968NHLBI NIH HHS R21 HL130901NHLBI NIH HHS R43 HL154866
6 · The paper itself

Abstract

Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.

Indexed as

BurnsElasticity Imaging TechniquesLung DiseasesAnimalsSwineTomography, Optical CoherenceTrachea

Identifiers

PMID33175676
PMCPMC8110609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.