Evidence map›Paper›PMID 33175598›Full record

ArticleMolecular biology of the cell2021

Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.

Thelma T Chiremba, Kristi L Neufeld

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. iScience · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thelma T ChirembaDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045.
Kristi L NeufeldDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045.ORCID 0000-0003-3653-9385
University of Kansas · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Small molecules modulating RNA-binding protein Msi1R01CA178831 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI NEUFELD, KRISTI L, XU, LIANG · 2014 to 2016
$1.3M
NCI NIH HHS P30 CA168524NCI NIH HHS R01 CA178831
6 · The paper itself

Abstract

Evolutionarily conserved RNA-binding protein Musashi1 (Msi1) can regulate developmentally relevant genes. Here we report the generation and characterization of a mouse model that allows inducible Msi1 overexpression in a temporal and tissue-specific manner. We show that ubiquitous Msi1 induction in ∼5-wk-old mice delays overall growth, alters organ-to-body proportions, and causes premature death. Msi1-overexpressing mice had shortened intestines, diminished intestinal epithelial cell (IEC) proliferation, and decreased growth of small intestine villi and colon crypts. Although

Indexed as

Growth and DevelopmentHomeostasisAnimalsCdc20 ProteinsCell ProliferationIntestinal MucosaIntestinesMembrane ProteinsMice, TransgenicMicrovilliModels, AnimalNerve Tissue ProteinsOrgan SpecificityReceptors, G-Protein-CoupledRNA-Binding ProteinsSerrate-Jagged ProteinsCdc20 protein, mouseCdc20 ProteinsLgr5 protein, mouseMembrane ProteinsMsi1h protein, mouseNerve Tissue ProteinsNumb protein, mouseReceptors, G-Protein-CoupledRNA-Binding ProteinsSerrate-Jagged Proteins

Identifiers

PMID33175598
PMCPMC8098822
OpenAlexW3100206352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.