Evidence map›Paper›PMID 33175479›Full record

ArticleCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology2020

Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt.

Vanessa M Baratta, Valentina Norz, Maria J Barahona, Teresa M Gisinger, David Mulligan, John P Geibel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vanessa M BarattaYale University, School of Medicine, Department of Surgery, New Haven, CT, USA.
Valentina NorzYale University, School of Medicine, Department of Surgery, New Haven, CT, USA.
Maria J BarahonaYale University, School of Medicine, Department of Surgery, New Haven, CT, USA.
Teresa M GisingerYale University, School of Medicine, Department of Surgery, New Haven, CT, USA.
David MulliganYale University, School of Medicine, Department of Surgery, New Haven, CT, USA.
John P GeibelYale University, School of Medicine, Department of Surgery, New Haven, CT, USA, john.geibel@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J. · 1986 to 2018
$29.5M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P01 DK017433NIDDK NIH HHS T32 DK007017
6 · The paper itself

Abstract

BACKGROUND/

aimsThe colonic H

methodsSprague Dawley rat colonic crypts were isolated and pHi changes were monitored through the ammonium prepulse technique. Increased proton extrusion in 0-Na

resultsIsolated administration of penG significantly increased H

conclusionOverall, acute exposure of colonic crypts to penG activates the H

Indexed as

AnimalsArginineColonH(+)-K(+)-Exchanging ATPaseMaleNG-Nitroarginine Methyl EsterNitric OxidePenicillin GRatsRats, Sprague-DawleyArginineH(+)-K(+)-Exchanging ATPaseNG-Nitroarginine Methyl EsterNitric OxidePenicillin G(3-5) Fluid secretion; H+, K+ ATPase; Nitric oxide pathway; Penicillin G; Colon

Identifiers

PMID33175479
PMCPMC8095381
OpenAlexW3101171417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.