ArticleThe EMBO journal2020
Paternal bloodlines sculpting seminal concepts: circulating factors as mediators of transgenerational 'epigenopathy' and 'epigenetic resilience'.
Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Parental Preconception Exposures to Outdoor Neighbourhood Environments and Adverse Birth Outcomes: A Protocol for a Scoping Review and Evidence Map.International journal of environmental research and public health · 2021Article
- Paternal bloodlines sculpting seminal concepts: circulating factors as mediators of transgenerational 'epigenopathy' and 'epigenetic resilience'.The EMBO journal · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence, particularly from rodent and human studies, shows that the environmental exposures and experience of a father prior to conception can modulate sperm epigenetics and subsequent offspring phenotypes. In this issue of The EMBO Journal, van Steenwyk and colleagues (2020) provide important new insights into how one form of paternal experience (early-life stress or trauma) may impact sperm epigenetics via circulating factors, presenting novel experimental evidence from a mouse model and an analogous human cohort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.