Evidence map›Paper›PMID 33175346›Full record

Trial reportDigestive diseases and sciences2021

Comprehensive Cognitive-Behavioral Interventions Augment Diaphragmatic Breathing for Rumination Syndrome: A Proof-of-Concept Trial.

Helen Burton Murray, Fengqing Zhang, Christine C Call, Ani Keshishian, Rowan A Hunt, Adrienne S Juarascio, Jennifer J Thomas

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Diagnostic and Management Review of Gastric and Supragastric Belching, Aerophagia, and Rumination Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Review
  3. Review
  4. Gastroparesis: Myths, Misconceptions, and Management.Clinical and experimental gastroenterology · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Helen Burton MurrayDepartment of Psychology, Drexel University, Philadelphia, PA, USA. hbmurray@mgh.harvard.edu.ORCID 0000-0003-2059-3256
Fengqing ZhangDepartment of Psychology, Drexel University, Philadelphia, PA, USA.
Christine C CallDepartment of Psychology, Drexel University, Philadelphia, PA, USA.
Ani KeshishianEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Rowan A HuntDepartment of Psychology, Drexel University, Philadelphia, PA, USA.
Adrienne S JuarascioDepartment of Psychology, Drexel University, Philadelphia, PA, USA.
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Drexel University · USHarvard University · USMassachusetts General Hospital · US

Funding

CLINICAL RESEARCH TRAINING FOR PSYCHOLOGISTST32MH018269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHELE D LEVINE · 1986 to 2026
$6.3M
NIMH NIH HHS T32 MH018269
6 · The paper itself

Abstract

backgroundRumination syndrome (RS) is often treated in medical settings with 1-2 sessions of diaphragmatic breathing to target reflexive abdominal wall contraction in response to conditioned cues (e.g., food). However, many patients remain symptomatic and require additional behavioral interventions.

aimsIn an attempt to augment diaphragmatic breathing with additional interventions, we tested the proof-of-concept of a comprehensive Cognitive-Behavioral Therapy (CBT) for RS.

methodsIn an uncontrolled trial, adults with RS completed a 5-8 session CBT protocol, delivered by one of two psychology behavioral health providers. CBT included two main phases: awareness training and diaphragmatic breathing (Phase 1) and modularized interventions chosen by the therapist and patient to target secondary maintenance mechanisms (Phase 2). At pre-treatment, post-treatment, and 3-month follow-up, participants completed a semi-structured interview on RS symptoms with an independent evaluator.

resultsOf 10 eligible individuals (ages 20-67 years, 50% female) offered treatment, all 10 initiated treatment and eight completed it. All participants endorsed high treatment credibility at Session 1. Permutation-based repeated measures ANOVA showed participants achieved large reductions in regurgitations across treatment [F(1,7) = 17.7, p = .007, η

conclusionsFindings provide evidence of feasibility, acceptability, and proof-of-concept for a comprehensive CBT for RS that includes interventions in addition to diaphragmatic breathing to target secondary maintenance mechanisms. Randomized controlled trials are needed.

Indexed as

Cognitive Behavioral TherapyAdultAgedFemaleHumansMaleMiddle AgedRumination SyndromeTreatment OutcomeYoung AdultDisorders of gut-brain interactionFeeding and eating disordersFunctional gastrointestinal disorderHabit-reversal trainingRumination disorderRumination syndrome

Identifiers

PMID33175346
PMCPMC8855660
OpenAlexW3100184377

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.