Evidence map›Paper›PMID 33175324›Full record

ReviewNeurotoxicity research2021

Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants.

Odia Osemwegie, Seshadri Ramkumar, Ernest E Smith

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Odia OsemwegieDepartment of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, TX, Lubbock, USA.
Seshadri RamkumarDepartment of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, TX, Lubbock, USA.
Ernest E SmithDepartment of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, TX, Lubbock, USA. Ernest.Smith@ttu.edu.ORCID http://orcid.org/0000-0002-6708-9412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

Indexed as

AnimalsAxonal TransportCytoplasmEnvironmental PollutantsHumansNeurodegenerative DiseasesNeuronal PlasticityNeuronsProteinsEnvironmental PollutantsProteinsEnvironmental contaminantsNeurodegenerationNeurofilament proteinsNeurotoxicity

Identifiers

PMID33175324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.