Evidence map›Paper›PMID 33175253›Full record

Trial reportClinical oral investigations2021

Saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia: a randomized controlled trial.

Dayaabaran Marimuthu, Kong Min Han, Mohd Shawal Firdaus Mohamad, Mawaddah Azman

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04491435 (Saliva Substitute Mouthwash in NPC Survivors With Xerostomia), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04491435 nacompletednot on this map

Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial

TypeinterventionalSponsorUniversiti Kebangsaan Malaysia Medical CentreRan2018 to 2020Enrolled94ConditionsXerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal CancerArmsSummated Xerostomia Inventory, Sialometry
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dayaabaran MarimuthuDepartment of Otorhinolaryngology and Head and Neck Surgery, Level 9, Clinical Block, UKM Medical Centre, National University of Malaysia Kuala Lumpur Campus, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia.
Kong Min HanDepartment of Otorhinolaryngology and Head and Neck Surgery, Level 9, Clinical Block, UKM Medical Centre, National University of Malaysia Kuala Lumpur Campus, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia.
Mohd Shawal Firdaus MohamadCentre of Studies for Oral and Maxillofacial Surgery, Faculty of Dentistry, UiTM Sungai Buloh Campus, Jalan Hospital, 47000, Sugai Buloh, Selangor, Malaysia.
Mawaddah AzmanDepartment of Otorhinolaryngology and Head and Neck Surgery, Level 9, Clinical Block, UKM Medical Centre, National University of Malaysia Kuala Lumpur Campus, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia. mawaddah1504@yahoo.com.ORCID http://orcid.org/0000-0001-9138-2849
University Kebangsaan Malaysia Medical Centre · MYHospital Sungai Buloh · MY

Funding

Universiti Kebangsaan Malaysia FF-2018-133
6 · The paper itself

Abstract

objectivesXerostomia is a prevalent sequelae among nasopharyngeal cancer (NPC) survivors; yet, effective treatment protocols have been elusive. This study was a prospective randomized clinical trial to compare the effects of saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia, between two treatment arms, conducted in a tertiary center. MATERIALS AND

methodsThis study measured the effects within 4 weeks in relation to summated xerostomia inventory (SXI) and unstimulated whole saliva (UWS). Patients randomized into the interventional arm were prescribed an immunologically active saliva substitute (IASS), while patients in the control arm were prescribed a non-immunologically active mouthwash as placebo.

resultsThe study population consisted of 94 patients. There was a significant difference in SXI difference (p < 0.0001) and UWS difference (p < 0.0001) between control and interventional arms. No harmful side effects associated with the use of either mouthwash encountered throughout the study duration.

conclusionIASS mouthwash significantly reduces subjective xerostomia scores measured using SXI and improves objective measurement of salivary flow using UWS among nasopharyngeal cancer survivors with xerostomia. CLINICAL RELEVANCE: IASS is significantly more effective in improving subjective and objective xerostomia measurements compared to non-immunologically active mouthwash. Additionally, this treatment is very safe, with superior side effect profiles.

trial registrationClinicalTrials.gov Identifier: NCT04491435.

Indexed as

Nasopharyngeal NeoplasmsXerostomiaHumansMouthwashesProspective StudiesSalivaSurvivorsMouthwashesHyposalivationMouth drynessMouthwashesNasopharyngeal cancerRadiation-induced toxicitySaliva artificialSaliva substituteXerostomia

Identifiers

PMID33175253
PMCPMC8060215
OpenAlexW3098553703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.