ArticleEJNMMI research2020
Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients.
Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Smaller is better? Compact vs. Conventional gamma camera for sentinel lymph node localization in patients with breast cancer.European journal of nuclear medicine and molecular imaging · 2025Trial
- Evaluation of Preoperative and Intraoperative Mobile Gamma Camera Imaging in Sentinel Lymph Node Biopsy for Melanoma Independent of Preoperative Lymphoscintigraphy.The Journal of surgical research · 2023Trial
- LiDAR-registered freehand SPECT combined with NIR-fluorescence enables spatial localisation of tracer-avid inguinal lymph nodes: A clinical feasibility study.European journal of nuclear medicine and molecular imaging · 2026Article
- Utilization of extended-reality technologies in the field of medical radiation.Radiological physics and technology · 2026Review
- Back-table specimen scanning using gantry-free hybrid hSPECT/LiDAR imaging: a feasibility study during PSMA-radioguided surgery.Surgical endoscopy · 2025Article
- Initial demonstration of the Scratch-PET concept: an intraoperative PET with a hand-held detector.Radiological physics and technology · 2025Article
- Optimization of Image Quality in Pelvis Lymphoscintigraphy SPECT/CT Using Discovery NM/CT 670.World journal of nuclear medicine · 2025Article
- Intraoperative radio-guided localization of parathyroid adenomas using 3D freehand SPECT technology.Updates in surgery · 2024Article
- Seracam: characterisation of a new small field of view hybrid gamma camera for nuclear medicine.EJNMMI physics · 2024Article
- Assessment of the axial resolution of a compact gamma camera with coded aperture collimator.EJNMMI physics · 2024Article
- Intraoperative Gamma Cameras: A Review of Development in the Last Decade and Future Outlook.Journal of imaging · 2023Review
- Study on intraoperative localization of sentinel lymph nodes using freehand SPECT in breast cancer patients.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAssessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar scintigraphy of an injected gamma-emitting lymphatic tracer followed by intraoperative node localization using a non-imaging gamma probe with auditory feedback. In recent years, intraoperative visualization of SLNs in 3D has become possible by coupling the probe to an external system capable of tracking its location and orientation as it is read out, thereby enabling computation of the 3D distribution of the tracer (freehand SPECT). In this project, the non-imaging probe of the fhSPECT system was replaced by a unique handheld gamma camera containing an array of sodium iodide crystals optically coupled to an array of silicon photomultipliers (SiPMs). A feasibility study was performed in which preoperative SLN mapping was performed using camera fhSPECT and the number of detected nodes was compared to that visualized by lymphoscintigraphy, probe fhSPECT, and to the number ultimately excised under non-imaging probe guidance.
resultsAmong five subjects, SLNs were detected in nine lymphatic basins, with one to five SLNs detected per basin. A basin-by-basin comparison showed that the number of SLNs detected using camera fhSPECT exceeded that using lymphoscintigraphy and probe fhSPECT in seven of nine basins and five of five basins, respectively. (Probe fhSPECT scans were not performed for four basins.) It exceeded the number excised under non-imaging probe guidance for seven of nine basins and equaled the number excised for the other two basins.
conclusionsFreehand SPECT using a prototype SiPM-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLN biopsy or radioguided tumor excision.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.