Evidence map›Paper›PMID 33175025›Full record

ArticleRevista de saude publica2020

Risk factors associated with antineoplastic chemotherapy-induced nausea and vomiting.

Giovana Paula Rezende Simino, Ilka Afonso Reis, Francisco de Assis Acurcio, Eli Iola Gurgel Andrade, Natalia Maria Linhares Brazil, Mariângela Leal Cherchiglia

Open access · goldAbstract read
In one paragraph

Article in Revista de saude publica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Giovana Paula Rezende SiminoUniversidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Básica. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-9814-3004
Ilka Afonso ReisUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0001-7199-8590
Francisco de Assis AcurcioUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Farmácia Social. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-5880-5261
Eli Iola Gurgel AndradeUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Preventiva e Social. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-0206-2462
Natalia Maria Linhares BrazilInstituto Mario Penna. Núcleo de Ensino e Pesquisa. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-8957-6430
Mariângela Leal CherchigliaUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Preventiva e Social. Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0001-5622-567X
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the incidence and to evaluate risk factors for antineoplastic nausea and vomiting with high and moderate emetogenic chemotherapy in adult patients in the first treatment cycle.

methodsProspective cohort study with follow-up of 269 adults during the first cycle of antineoplastic chemotherapy. The incidence of nausea and vomiting was evaluated in the acute phase (0-24 hours), in the late phase (24 hours-5th day) and in the total phase (0-5th day).

resultsIn total, 152 patients underwent high emetogenic chemotherapy and 117 moderate emetogenic chemotherapy. The relative frequency of nausea was higher when compared with vomiting in the acute phase (p < 0.001) and in the late phase (p < 0.001). The risk factors identified were: age group ≤ 49 years (odds ratio = 0.47; 95%CI 0.23-0.95) and 50-64 years (odds ratio = 0.45; 95%CI 0.23-0.87), tobacco use (odds ratio = 0.35; 95%CI 0.14-0.88), and high emetogenic chemotherapy (odds ratio 0.55; 95%CI 0.31-0.95).

conclusionThe incidence of nausea was higher than that of vomiting, and adverse effects were more frequent in the late phase. The results suggest the risk factors for chemotherapy-induced nausea and vomiting are tobacco, age (young adults), and high emetogenic chemotherapy.

Indexed as

AdultAgedAged, 80 and overAntiemeticsAntineoplastic AgentsBrazilCohort StudiesFemaleHumansIncidenceMaleMiddle AgedNauseaNeoplasmsProspective StudiesRisk FactorsAntiemeticsAntineoplastic Agents

Identifiers

PMID33175025
PMCPMC7647467
OpenAlexW3095136448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.