Evidence map›Paper›PMID 33174626›Full record

Trial reportClinical pharmacology and therapeutics2021

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail.

James T Nguyen, Dan-Dan Tian, Rakshit S Tanna, Deena L Hadi, Sumit Bansal, Justina C Calamia, Christopher M Arian, Laura M Shireman, Bálint Molnár, Miklós Horváth and 8 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical pharmacology and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05081583 (Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05081583 early_phase1completednot on this map

Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients

TypeinterventionalSponsorWashington State UniversityRan2021 to 2023Enrolled22ConditionsInteraction, Adverse Herb-Drug, Diabetes Mellitus, Type 2ArmsMidazolam Hcl 1Mg/Ml Inj, Goldenseal (Hydrastis canadensis)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

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  16. Translating Kratom-Drug Interactions: From Bedside to Bench and Back.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

James T NguyenDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Dan-Dan TianDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Rakshit S TannaDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Deena L HadiDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Sumit BansalDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Justina C CalamiaDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Christopher M ArianDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Laura M ShiremanDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Bálint MolnárSOLVO Biotechnology, SZTE Biológiai Epület, University of Szeged, Szeged, Hungary.
Miklós HorváthSOLVO Biotechnology, SZTE Biológiai Epület, University of Szeged, Szeged, Hungary.
Joshua J KelloggDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Matthew E LaytonElson S. Floyd College of Medicine, Washington State University, Spokane, Washington, USA.
John R WhiteDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Nadja B CechCenter of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Richard D BoyceCenter of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Jashvant D UnadkatCenter of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Kenneth E ThummelCenter of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Mary F PaineDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Washington State University Spokane · USUniversity of Washington · USUniversity of North Carolina at Greensboro · USUniversity of Szeged · HUUniversity of Pittsburgh · US

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI BOYCE, RICHARD DAVID · 2015 to 2024
$22.4M
NCCIH NIH HHS U54 AT008909
6 · The paper itself

Abstract

The botanical natural product goldenseal can precipitate clinical drug interactions by inhibiting cytochrome P450 (CYP) 3A and CYP2D6. Besides P-glycoprotein, effects of goldenseal on other clinically relevant transporters remain unknown. Established transporter-expressing cell systems were used to determine the inhibitory effects of a goldenseal extract, standardized to the major alkaloid berberine, on transporter activity. Using recommended basic models, the extract was predicted to inhibit the efflux transporter BCRP and uptake transporters OATP1B1/3. Using a cocktail approach, effects of the goldenseal product on BCRP, OATP1B1/3, OATs, OCTs, MATEs, and CYP3A were next evaluated in 16 healthy volunteers. As expected, goldenseal increased the area under the plasma concentration-time curve (AUC

Indexed as

Herb-Drug InteractionsHydrastisAdultAlkaloidsBiological ProductsCross-Over StudiesDrug EvaluationFemaleFurosemideHEK293 CellsHumansMaleMetforminMidazolamOrganic Anion TransportersOrganic Cation Transport ProteinsAlkaloidsBiological ProductsFurosemideMetforminMidazolamOrganic Anion TransportersOrganic Cation Transport ProteinsPlant ExtractsRosuvastatin Calcium

Identifiers

PMID33174626
PMCPMC8058163
OpenAlexW3103924104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.