Evidence map›Paper›PMID 33174596›Full record

ArticleNucleic acids research2021

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.

Sneha Rath, Rohit Sharma, Rahul Gupta, Tslil Ast, Connie Chan, Timothy J Durham, Russell P Goodman, Zenon Grabarek, Mary E Haas, Wendy H W Hung and 22 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,182 papers.

0numbers the graph read from it
0cells of the map it votes in
1,182citing papers in PubMed
70.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,182 citing papers in PubMed, 1,872 citations in OpenAlex.

  1. DRP1 depletion protects NK cells from hypoxia-induced dysfunction.Redox report : communications in free radical research · 2026
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  3. Prognostic model construction and drug prediction in colorectal cancer using mitochondrial programmed cell death-related genes.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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1,122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 1 institution in 1 country.

Sneha RathBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rohit SharmaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rahul GuptaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tslil AstBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Connie ChanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Timothy J DurhamBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Russell P GoodmanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zenon GrabarekBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Mary E HaasBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wendy H W HungBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Pallavi R JoshiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alexis A JourdainBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sharon H KimBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Anna V KotrysBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Stephanie S LamBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jason G McCoyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joshua D MeiselBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Maria MirandaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Apekshya PandaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Anupam PatgiriBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Robert RogersBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Shayan SadreBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hardik ShahBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Owen S SkinnerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tsz-Leung ToBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Melissa A WalkerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hong WangBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Patrick S WardBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jordan WengrodBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chen-Ching YuanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sarah E CalvoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vamsi K MoothaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Broad Institute · US

Funding

Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Structure, function, and disease biology of MICU1/MICU2R01AR071942 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Zenon Grabarek, Vamsi Krishna Mootha · 2018 to 2026
$4.1M
Mitochondrial Parts, Pathways, and PathogenesisR35GM122455 · NIGMS · BROAD INSTITUTE, INC. · PI MOOTHA, VAMSI KRISHNA · 2017 to 2021
$4.0M
A METABOLIC BIOMARKER OF HEPATIC NADH/NAD+ RATIOK08DK115881 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GOODMAN, RUSSELL PAUL · 2018 to 2022
$865k
Molecular Determinants of Mitochondrial Genome Abundance and IntegrityK00CA212468 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2019 to 2022
$385k
Characterizing the biochemical regulation of mitochondrial one-carbon metabolismF32GM133047 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SKINNER, OWEN SAMUEL · 2019 to 2021
$153k
Elucidating the mechanism of hypoxia rescue of mitochondrial dysfunctionF32GM128259 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LAM, STEPHANIE SHIH-MIN · 2018 to 2020
$151k
Howard Hughes Medical InstituteNIDDK NIH HHS K08 DK115881NIGMS NIH HHS F32 GM128259NIGMS NIH HHS F32 GM133047
6 · The paper itself

Abstract

The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include manually curated annotations of sub-mitochondrial localization (matrix, inner membrane, intermembrane space, outer membrane) as well as assignment to 149 hierarchical 'MitoPathways' spanning seven broad functional categories relevant to mitochondria. MitoCarta3.0, including sub-mitochondrial localization and MitoPathway annotations, is freely available at http://www.broadinstitute.org/mitocarta and should serve as a continued community resource for mitochondrial biology and medicine.

Indexed as

Databases, ProteinMolecular Sequence AnnotationAnimalsBayes TheoremDatasets as TopicDNA, MitochondrialHumansInternetMachine LearningMass SpectrometryMiceMitochondriaMitochondrial MembranesMitochondrial ProteinsProteomeSoftwareDNA, MitochondrialMitochondrial ProteinsProteome

Identifiers

PMID33174596
PMCPMC7778944
OpenAlexW3106539179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.