Evidence map›Paper›PMID 33174475›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition.

Clare Walton, Rachel King, Lindsay Rechtman, Wendy Kaye, Emmanuelle Leray, Ruth Ann Marrie, Neil Robertson, Nicholas La Rocca, Bernard Uitdehaag, Ingrid van der Mei and 5 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1,281 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,281citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06167447 completednot on this mapstarted 2021, after this paper: background citation

Evaluation Of The Existence Of Kinesiophobia In Patients With Multiple Sclerosis; Effect Of Kinesiophobia On Physical Activity,Functional Status, Quality Of Life and Depression

TypeobservationalSponsorGazi UniversityRan2021 to 2021Enrolled90ConditionsMultiple Sclerosis, KinesiophobiaArmsquestionnaire and examination
NCT06949956 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Administration of Fingolimod in Greek Patients With Multiple Sclerosis for the Evaluation of the Efficacy and Safety, Based on the Standard Clinical Practice.

TypeobservationalSponsorElpen Pharmaceutical Co. Inc.Ran2025 to 2027Enrolled140ConditionsRelapsing Remitting Multiple Sclerosis
NCT07230015 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effectiveness of Combination of Motor Imagery and Vestibular Rehabilitation on Balance, Cognition, and Quality of Life in Patients With Multiple Sclerosis

TypeinterventionalSponsorMedipol UniversityRan2025 to 2026Enrolled30ConditionsMultiple Sclerosis (MS) - Relapsing-remittingArmsMotor Imagery + Vestibular Rehabilitation group, Conventional therapy group
3 · Its place in the literature

Who cites it

1,281 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Smoking and disability outcomes in multiple sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Trial
  20. Trial

1,221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Clare WaltonMultiple Sclerosis International Federation, London, UK.ORCID 0000-0002-8128-6439
Rachel KingMultiple Sclerosis International Federation, London, UK.
Lindsay RechtmanMcKing Consulting Corporation, Atlanta, GA, USA.
Wendy KayeMcKing Consulting Corporation, Atlanta, GA, USA.
Emmanuelle LerayEA 7449 REPERES, Epidemiology, Ecole des Hautes Etudes en Sante Publique, Rennes, France.
Ruth Ann MarrieInternal Medicine, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
Neil RobertsonInstitute of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK.
Nicholas La RoccaNational MS Society, West Bath, ME, USA.
Bernard UitdehaagNeurology, Amsterdam UMC-Locatie VUMC, Amsterdam, Netherlands.
Ingrid van der MeiMenzies Research Institute, University of Tasmania, Hobart, TAS, Australia.
Mitchell WallinDepartment of Neurology, George Washington University, Washington, DC, USA.
Anne HelmeMultiple Sclerosis International Federation, London, UK.
Ceri Angood NapierMultiple Sclerosis International Federation, London, UK.
Nick RijkeMultiple Sclerosis International Federation, London, UK.
Peer BanekeMultiple Sclerosis International Federation, London, UK.

Funding

Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

backgroundHigh-quality epidemiologic data worldwide are needed to improve our understanding of disease risk, support health policy to meet the diverse needs of people with multiple sclerosis (MS) and support advocacy efforts.

objectivesThe Atlas of MS is an open-source global compendium of data regarding the epidemiology of MS and the availability of resources for people with MS reported at country, regional and global levels.

methodsCountry representatives reported epidemiologic data and their sources via survey between September 2019 and March 2020, covering prevalence and incidence in males, females and children, and age and MS type at diagnosis. Regional analyses and comparisons with 2013 data were conducted.

resultsA total of 2.8 million people are estimated to live with MS worldwide (35.9 per 100,000 population). MS prevalence has increased in every world region since 2013 but gaps in prevalence estimates persist. The pooled incidence rate across 75 reporting countries is 2.1 per 100,000 persons/year, and the mean age of diagnosis is 32 years. Females are twice as likely to live with MS as males.

conclusionsThe global prevalence of MS has risen since 2013, but good surveillance data is not universal. Action is needed by multiple stakeholders to close knowledge gaps.

Indexed as

Multiple SclerosisChildFemaleHumansIncidenceMalePrevalenceepidemiologyMultiple sclerosis

Identifiers

PMID33174475
PMCPMC7720355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.