ArticleNeurogastroenterology and motility2021
Association between pain sensitivity and gray matter properties in the sensorimotor network in women with irritable bowel syndrome.
Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Causal relationships between irritable bowel syndrome and brain functional networks: A Mendelian randomization study.Journal of translational internal medicine · 2026Article
- Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026Review
- Disrupted prefrontal-sensorimotor functional connectivity mediates the association between depression and symptom severity in patients with irritable bowel syndrome.Frontiers in human neuroscience · 2026Article
- Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review.World journal of methodology · 2025Article
- Disentangling sex-specific mechanisms in neuropathic and nociplastic chronic pain: a review.Frontiers in neurology · 2025Review
- A multidisciplinary approach to the management of disorders of gut-brain interaction: psychopharmacology, psychotherapy, and diet.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Impact of Enteric Nervous Cells on Irritable Bowel Syndrome: Potential Treatment Options.Microorganisms · 2024Review
- Interoceptive Processing in Functional Gastrointestinal Disorders.International journal of molecular sciences · 2024Review
- Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling.Frontiers in neuroscience · 2024Article
- Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment.World journal of gastroenterology · 2023Review
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms.NeuroImage. Clinical · 2022Article
- Altered Structural Covariance of Insula, Cerebellum and Prefrontal Cortex Is Associated with Somatic Symptom Levels in Irritable Bowel Syndrome (IBS).Brain sciences · 2021Article
- Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms.Frontiers in neuroscience · 2021Article
- Aberrant anterior insula-sensorimotor interaction modulates pain empathy in women with primary dysmenorrhea.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundEnhanced perception of visceral stimuli is an important feature of Irritable Bowel Syndrome (IBS), but it is not known whether visceral sensitivity is associated with regional structural brain properties in IBS.
methodsStructural brain magnetic resonance imaging data from 216 women with IBS and 138 healthy women were parcellated with FreeSurfer to define regional gray matter morphometry (volume, cortical thickness, surface area and mean curvature) in the sensorimotor network. General linear models were used to detect group differences between IBS and health. In a second set of 48 female IBS patients, pain threshold, pain intensity ratings during rectal balloon distension, and reported levels of abdominal pain and bloating were correlated with brain regions that showed differences between IBS and health in the first data set. KEY
resultsSeveral statistically significant differences between IBS patients and healthy controls were found, mainly higher gray matter volume and cortical thickness in primary somatosensory cortex, secondary somatosensory cortex, and subcortical regions, and lesser gray matter volume, surface area and cortical thickness in posterior insula and superior frontal gyrus. Pain intensity ratings during rectal distension were associated with left primary somatosensory cortical thickness, and pain threshold was associated with right nucleus accumbens volume. CONCLUSIONS AND INFERENCES: Regional gray matter differences in sensorimotor network are associated with visceral sensitivity and may represent neuroplastic changes in female IBS patients.
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