ArticleReproductive sciences (Thousand Oaks, Calif.)2021
Effect of Embryo Developmental Stage, Morphological Grading, and Ploidy Status on Live Birth Rate in Frozen Cycles of Single Blastocyst Transfer.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pregnancy and perinatal outcomes after day 5 versus day 6 blastocyst-stage embryo transfer: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Cleavage-stage stratification reveals the clinical and developmental potential of 0PN embryos compared with 2PN embryos in IVF.Frontiers in endocrinology · 2026Article
- Inner Cell Mass Grade and Earlier Blastulation Are Associated with Pregnancy Outcomes in Euploid Embryos.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Effect of Blastocyst Morphology and Developmental Rate on Euploidy and Live Birth Rates in PGT-A Cycles: A Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Endometrial preparation protocols did not impact outcomes after frozen-thaw embryo transfer for chronic endometritis treatment.Contraception and reproductive medicine · 2025Article
- Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status.Frontiers in endocrinology · 2025Article
- Fresh Versus Frozen Embryo Transfer in Women with Repeated Implantation Failure.Advanced biomedical research · 2025Article
- Effect of day 5 or 6 blastocyst embryo transfer on pregnancy outcomes in euthyroid women undergoing IVF: A single centre retrospective cohort.JBRA assisted reproduction · 2024Article
- Article
- Antibiotics improve reproductive outcomes after frozen-thaw embryo transfer for chronic endometritis treatment, especially in those with repeated implantation failure.BMC women's health · 2024Article
- Prioritized single vitrified blastocyst to be warmed between grades 3 or 4 blastocyst on day 5 transfer cycles.Archives of gynecology and obstetrics · 2024Article
- The correlation between morphological parameters and the incidence of de novo chromosomal abnormalities in 3238 biopsied blastocysts.Journal of assisted reproduction and genetics · 2023Article
- Microbiological and Cytokine Profiling of Menstrual Blood for the Assessment of Endometrial Receptivity: A Pilot Study.Biomedicines · 2023Article
- Trophectoderm biopsy is associated with adverse obstetric outcomes rather than neonatal outcomes.BMC pregnancy and childbirth · 2023Article
- No advantage of single day 6 good-quality blastocyst transfer versus single day 5 poor-quality blastocyst transfer in frozen-thawed cycles stratified by age: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?BMC pregnancy and childbirth · 2022Article
- Day 5 vs day 6 single euploid blastocyst frozen embryo transfers: which variables do have an impact on the clinical pregnancy rates?Journal of assisted reproduction and genetics · 2022Article
- Functional Ovarian Cysts in Artificial Frozen-Thawed Embryo Transfer Cycles With Depot Gonadotropin-Releasing Hormone Agonist.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether embryo developmental stage or morphological grading can predict live birth rate (LBR) from a single blastocyst in nonbiopsied and biopsied frozen embryo transfer (FET) cycles. This retrospective study included 1336 nonbiopsied and 360 euploid FET cycles. Blastocysts were divided according to developmental stage (day 5 [D5] and day 6 [D6]) and morphology (good quality and low quality). Nonbiopsied cycles in which D5 blastocysts were transferred were associated with a significantly higher LBR than those in the D6 group (48.5 vs. 24.3%; p < 0.001), as well as in good-quality embryo transfer cycles than that in low-quality embryo cycles (52.6 vs. 25.3%; p < 0.001). Embryos reaching good-quality blastocysts on D5 yielded significantly higher LBR than those similar quality blastocysts on D6. The same trend was seen in low-quality embryos. Concerning only D5 or D6 blastocyst transfer, the LBRs of good-quality embryos were still superior to those of low-quality embryos. In the case of euploid embryo transfers, the LBR (48.9 vs. 44.9%, p = 0.444) of D5 blastocysts did not significantly differ from that of D6 blastocysts. Good-quality embryos showed a higher LBR than low-quality embryos (51.6 vs. 40.0%, p = 0.030); the adjusted odds ratio remained insignificant after controlling for confounders (aOR 1.56; 95% CI 0.99-2.45; p = 0.056). The LBRs in the same developmental stage or morphology subgroups were not statistically significant. Embryo developmental stage and morphological grade are useful predictors of LBR in nonbiopsied FET cycles. However, no association was found in euploid transfer cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.