ArticleProceedings of the National Academy of Sciences of the United States of America1987
The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 123 citations in OpenAlex.
- Cell replacement in the degenerating cerebellum: a historical essay of discovery.Journal of neurology · 2025Review
- Roles of Cbln1 in Non-Motor Functions of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- All the way from the cortex: a review of auditory corticosubcollicular pathways.Cerebellum (London, England) · 2015Review
- Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- The Cbln family of proteins interact with multiple signaling pathways.Journal of neurochemistry · 2012Article
- Cbln1 and the δ2 glutamate receptor--an orphan ligand and an orphan receptor find their partners.Cerebellum (London, England) · 2012Review
- Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice.Journal of neurochemistry · 2012Article
- The unipolar brush cell: a remarkable neuron finally receiving deserved attention.Brain research reviews · 2011Review
- Extracerebellar role for Cerebellin1: modulation of dendritic spine density and synapses in striatal medium spiny neurons.The Journal of comparative neurology · 2010Article
- Cross-modal interactions of auditory and somatic inputs in the brainstem and midbrain and their imbalance in tinnitus and deafness.American journal of audiology · 2008Review
- Distribution and phenotypes of unipolar brush cells in relation to the granule cell system of the rat cochlear nucleus.Neuroscience · 2008Article
- Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Multimodal inputs to the granule cell domain of the cochlear nucleus.Experimental brain research · 2003Review
- Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Cbln3, a novel member of the precerebellin family that binds specifically to Cbln1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Granule cell activation of complex-spiking neurons in dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- The unipolar brush cells of the rat cerebellar cortex and cochlear nucleus are calretinin-positive: a study by light and electron microscopic immunocytochemistry.Anatomy and embryology · 1994Article
- Cerebellar degeneration in the Niemann-Pick type C mouse.Acta neuropathologica · 1993Article
- Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
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2 authors at 1 institution in 1 country.
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Abstract
We report here that the neuropeptide cerebellin, a known marker of cerebellar Purkinje cells, has only one substantial extracerebellar location, the dorsal cochlear nucleus (DCoN). By reverse-phase high-performance liquid chromatography and radioimmunoassay, cerebellum and DCoN in rat were found to contain similar concentrations of this hexadecapeptide. Immunocytochemistry with our rabbit antiserum C1, raised against synthetic cerebellin, revealed that cerebellin-like immunoreactivity in the cerebellum is localized exclusively to Purkinje cells, while in the DCoN, it is found primarily in cartwheel cells and in the basal dendrites of pyramidal neurons. Some displaced Purkinje cells were also stained. Although cerebellum and DCoN receive their inputs from different brain regions, their organizations show several similarities, with many neuronal cell types present in one having their presumed homologue in the other. Cerebellin is present in Purkinje and cartwheel cells throughout the cerebellum and the DCoN without site predilection. This should be viewed together with recent data indicating that these two classes of neurons share a similar fate in several murine mutations ("nervous," "lurcher," "Purkinje cell degeneration," and "staggerer"). This situation leads us to conclude that cerebellin represents a marker for a small number of spatially related neuronal cell classes, and that it may play a role in an as yet unknown aspect of a circuit function worthy of further exploration.
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