ArticleEnvironmental science and pollution research international2021
Investigation of oxidative stress enzymes and histological alterations in tilapia exposed to chlorpyrifos.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- The protective role of Artemisia annua against chlorpyrifos toxicity in Nile tilapia.Scientific reports · 2026Article
- Toxic effect of organophosphate (chlorpyrifos) on hematological, biochemical, enzymatic and histological parameters in striped catfish (Pangasianodon hypophthalmus, Sauvage, 1878).Scientific reports · 2026Article
- Histopathology based study of Nile tilapia fish (Oreochromis niloticus) as a biomarker for water pollution evaluation in the southern gulf of Lake Tana, Ethiopia.BMC veterinary research · 2024Article
- Assessing organophosphate insecticide retention in muscle tissues of juvenile common carp fish under acute toxicity tests.Toxicology reports · 2024Article
- Review
- Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism.Frontiers in physiology · 2023Review
- Toxic effects of chlorpyrifos on the growth, hematology, and different organs histopathology of Nile tilapia,Saudi journal of biological sciences · 2022Article
- Agriculture Development, Pesticide Application and Its Impact on the Environment.International journal of environmental research and public health · 2021Review
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos (ChF) is an organophosphate pesticide that is widely used in agricultural fields and indoor for controlling pests. Aquatic ecosystems are the recipients of various pesticide residues due to leaching spray drift and agricultural runoff and pose toxicity for aquatic organisms. Therefore, the current study was designed to investigate the oxidative stress enzymes and histological alterations in the vital organs of tilapia due to ChF exposure. LC50 (24 h) was calculated as 52.78 μg/l by exposing tilapia with different acute concentrations of ChF. For assessment of sub-lethal toxicity of ChF, the fish were divided into four groups (ChF1, ChF2, ChF3, and control group). ChF1 group was treated with 1/15th of LC50, whereas ChF2 and ChF3 groups were treated with 1/10th and 1/5th of LC50, respectively for 14 days. After that, ChF induced changes in oxidative stress enzymes and histological alterations were evaluated. It was found that the level of glutathione S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) increased significantly in the liver of ChF-treated tilapia. Histological study of liver tissues showed an increased number of Kupffer cells, hydropic degeneration, necrosis, and hemorrhage. In the spleen of treated fish, increased melanomacrophage centers, necrosis, and congestion were detected. Disorganized muscle fibers, cardiac muscle fiber degeneration, and coagulative necrosis were observed in the heart of ChF-treated fish. It is concluded that sub-lethal concentrations of ChF can induce oxidative stress and histological alterations in the tissues of tilapia.
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