ArticleNeuroscience bulletin2020
Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival.
Article in Neuroscience bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Asexuality in Drosophila juvenile males is organizational and independent of juvenile hormone.EMBO reports · 2023Article
- A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila.Neuroscience bulletin · 2023Article
- Neural Control of Action Selection Among Innate Behaviors.Neuroscience bulletin · 2022Review
- Serotonin Signaling Modulates Sexual Receptivity of Virgin Female Drosophila.Neuroscience bulletin · 2022Article
- Hormonal control of motivational circuitry orchestrates the transition to sexuality inScience advances · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some semelparous organisms in nature mate as many times as they can in a single reproductive episode before death, while most iteroparous species including humans avoid such suicidal reproductive behavior. Animals naturally pursue more sex and the possible fatal consequence of excessive sex must be orchestrated by negative feedback signals in iteroparous species, yet very little is known about the regulatory mechanisms. Here we used Drosophila male sexual behavior as a model system to study how excessive sex may kill males and how the nervous system reacts to prevent death by sex. We found that continuous sexual activity by activating the fruitless-expressing neurons induced a fixed multi-step behavioral pattern ending with male death. We further found negative feedback in the fly brain to prevent suicidal sexual behavior by expression changes of the neurotransmitters acetylcholine and gamma-aminobutyric acid, and neuropeptide F. These findings are crucial to understand the molecular underpinnings of how different organisms choose reproductive strategies and balance reproduction and survival.
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Registered trials
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