Evidence map›Paper›PMID 33174160›Full record

ArticleArchives of toxicology2021

Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB

Ken-Ichi Tomiyama, Masahiko Funada

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Changes of CB1 Receptor Expression in Tissues of Cocaine-Exposed Eels.Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ken-Ichi TomiyamaDepartment of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8553, Japan.
Masahiko FunadaDepartment of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8553, Japan. mfunada@ncnp.go.jp.ORCID http://orcid.org/0000-0003-1330-7522
National Center of Neurology and Psychiatry · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytotoxicity of the synthetic cannabinoid CP-55,940, a compound that acts equally on both types of cannabinoid receptors (CB

Indexed as

ApoptosisAnnexinsCalciumCalcium Channel BlockersCalcium Channels, L-TypeCannabinoidsCaspase 3Cell Line, TumorCell SurvivalCyclohexanolsHumansMembrane Potential, MitochondrialMuscle, SkeletalOxygenReceptor, Cannabinoid, CB13-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAnnexinsCalciumCalcium Channel BlockersCalcium Channels, L-TypeCannabinoidsCaspase 3CyclohexanolsOxygenReceptor, Cannabinoid, CB1ApoptosisCannabinoid (CB1) receptorCaspase-3L-type calcium channelMitochondrial membrane potentialRhabdomyosarcoma (RD) cell lineSynthetic cannabinoid CP-55,940

Identifiers

PMID33174160
OpenAlexW3105665871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.