ArticleInternational journal of colorectal disease2021
Stage migration resulting from inadequate number of examined lymph nodes impacts prognosis in stage II colon cancer after radical surgery.
Article in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nodal stage is the key prognostic factor in synchronous and metachronous multiple primary colorectal adenocarcinoma after curative-intent resection: a retrospective study.World journal of surgical oncology · 2026Article
- Efficacy of adjuvant chemotherapy in stage II colon cancer patients with twelve or more lymph nodes retrieve.World journal of gastrointestinal oncology · 2025Article
- Optimal number of the examined lymph nodes for different N stages in colorectal cancer.European journal of medical research · 2025Article
- Elevated postoperative carcinoembryonic antigen guides adjuvant chemotherapy for stage II colon cancer: a multicentre cohort retrospective study.Scientific reports · 2024Article
- Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.Clinical & experimental metastasis · 2024Article
- Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis.Surgery in practice and science · 2023Review
- The effect of preoperative endoscopic tattooing using India ink on lymph node yield in laparoscopic colectomy for stage I right-sided colon cancer.International journal of colorectal disease · 2023Article
- New staging systems for left-sided colon cancer based on the number of retrieved and metastatic lymph nodes provide a more accurate prognosis.Pathology oncology research : POR · 2023Article
- Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeWe evaluated the impact of examined lymph node (ELN) number on the prognosis of stage II colon cancer after radical surgery and developed a novel prognostic scoring system by combining primary tumor extension (pT) and ELN number for reclassification of stage II colon cancer.
methodsThree cohorts of patients diagnosed with colon cancer between 2004 and 2010 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate analyses were performed to evaluate the relationship between factors and patients' survival including cause-specific survival (CSS) and overall survival (OS). Survival curves from subgroups were plotted by the Kaplan-Meier method and compared by the log-rank test.
resultsCohort 1 and cohort 2 consisted of 13,960 and 5312 stage II colon cancer patients, respectively. Cohort 3 consisted of 4713 stage III patients. Factors including ELN, age, and pT were found to be associated with patients' survival in cohorts 1 and 2. Patients who were older or with smaller tumors were more likely to experience inadequate ELN. Patients with a higher score, as calculated by the novel scoring system, showed worse survival. Compared with stage III colon cancer patients, stage II patients with high scores had a comparable or even worse survival than stage IIIA and IIIB patients.
conclusionInadequate ELN leads to understaging in stage II colon cancer and predicts inferior prognosis. Our analyses show that the novel prognostic scoring system, consisting of combined pT and ELN, quantified stage migration effect and can be applied to the reclassification of stage II colon cancer.
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