SynthesisJournal of neurology2021
Central retina changes in Parkinson's disease: a systematic review and meta-analysis.
Synthesis in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optical coherence tomography angiography measurements in Parkinson's disease: A systematic review and meta-analysis.Eye (London, England) · 2023Pooled it
- Retina thickness in atypical parkinsonism: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Association Between Substantia Nigra Hyperechogenicity and Central Macular Thickness in Parkinson's Disease.Biomedicines · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Detailed Outer Retinal Assessment in Parkinson's Disease Using Directional OCT.Investigative ophthalmology & visual science · 2026Article
- Article
- The Retina as a Biomarker for Parkinson's Disease: A Systematic Review.Neuro-ophthalmology (Aeolus Press) · 2026Review
- Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Retinal Thickness in Patients with Parkinson's Disease and Dopa Responsive Dystonia-Is There Any Difference?Biomedicines · 2025Article
- Keeping an eye on Parkinson's disease: color vision and outer retinal thickness as simple and non-invasive biomarkers.Journal of neurology · 2025Review
- Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease.Annals of clinical and translational neurology · 2025Article
- Dynamics of retinal changes in early-stage Parkinson's disease.Acta neuropathologica communications · 2025Article
- Changes in Visual Evoked Potential and Optical Coherence Tomography in Parkinson's Disease: A Systematic Review and Meta-Analysis.Parkinson's disease · 2025Review
- Retinal hyperspectral imaging in mouse models of Parkinson's disease and healthy aging.Scientific reports · 2024Article
- Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection.Acta neuropathologica communications · 2024Article
- [Retinal OCT biomarkers and neurodegenerative diseases of the central nervous system beyond Alzheimer's disease].Die Ophthalmologie · 2024Review
- Fractal Phototherapy in Maximizing Retina and Brain Plasticity.Advances in neurobiology · 2024Article
- Altered Outer Retinal Structure, Electrophysiology and Visual Perception in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease.Neurology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCentral retina imaging is important for early Parkinson's disease (PD) recognition. We aimed to investigate central retina changes using spectral domain-optical coherence tomography (SD-OCT) in PD patients.
methodsWe systematically searched PubMed and EMBASE to identify studies comparing the whole or individual layer thickness of central retina between PD patients and health controls using SD-OCT from inception to April 25, 2020. Data were extracted at eye level. We pooled the mean difference with random effects model. Subgroup analysis and mete-regression were done to detect possible source of heterogeneity.
resultsWe included 27 studies (28 sets of data) enrolling 1470 PD patients (2288 eyes) and 1552 health controls (2524 eyes) in our meta-analysis. Compared with control eyes, the whole thickness of central retina decreased significantly at fovea center by mean difference - 2.70 μm (95% CI [- 4.87, - 0.53], p = 0.01) and in all quadrants in PD eyes. The combination of ganglion cell layer and inner plexiform layer thinned by an average mean difference of - 3.17 μm (95% CI [- 5.07, - 1.26], p = 0.001). The nerve fiber layer thinned by an average mean difference - 0.66 μm (95% CI [- 1.09 to - 0.23], p = 0.003). There was no significant difference in the thickness of inner nuclear layer, outer plexiform layer and outer nuclear layer between eyes of PD and controls. The results of subgroup analysis and mete-regression were consistent.
conclusionThe whole thickness, the thickness of the combination of ganglion cell layer and inner plexiform layer, and nerve fiber layer of central retina decreased significantly in PD patients.
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