Observational studyJapanese journal of ophthalmology2021
Relationships between the vascular structure and neural function of the macula in patients with diabetes mellitus.
Observational study in Japanese journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Macular thickness and vascular density assessment using optical coherence tomography and optical coherence tomography angiography imaging in iron ore mine personnel.International journal of retina and vitreous · 2025Article
- Evaluation of optical coherence tomography angiography and pattern and flash electroretinography in diabetes mellitus without retinopathy.Annals of medicine · 2024Article
- Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation.Diabetologia · 2024Article
- Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection.Frontiers in pharmacology · 2024Article
- Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.Journal of clinical medicine · 2023Article
- Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography.Scientific reports · 2023Article
- Pre-Ophthalmoscopic Quantitative Biomarkers in Diabetes Mellitus.Translational vision science & technology · 2023Article
- Longer Interscan Times in OCT Angiography Detect Slower Capillary Flow in Diabetic Retinopathy.Ophthalmology science · 2022Article
- Early Microvascular and Oscillatory Potentials Changes in Human Diabetic Retina: Amacrine Cells and the Intraretinal Neurovascular Crosstalk.Journal of clinical medicine · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine the significance of the correlation between the vascular structure and neural function of the macula in patients with diabetes mellitus. STUDY
designSingle-center observational study. PATIENTS AND
methodsNinety eyes of 90 diabetic patients with an average (SD) age of 63.5 (3.8) years were studied. Fifty of the eyes had no clinically apparent diabetic retinopathy (non-DR), and 40 eyes had mild-to-moderate nonproliferative DR (NPDR). Thirty age-matched healthy individuals were also studied in the same way. Swept-source optical coherence tomography angiography (OCTA) was performed to obtain 3 × 3-mm en face images of the posterior pole of the eye. The vascular densities (VDs) of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were determined. The focal macular electroretinograms (ERGs) elicited by a 15° circular stimulus centered on the fovea were recorded. The amplitudes of the a- and b-waves, sum of the oscillatory potentials (ΣOPs), photopic negative response (PhNR), and implicit times of the individual OPs (OP1-OP3) were measured.
resultsThe VDs of the SCP and DCP were reduced in eyes with advanced DR (P < .01 for SCP). The implicit times of OP1-OP3 were significantly prolonged in eyes with a lower VD of the SCP and DCP in the non-DR group (P < .05). The amplitudes of the ΣOPs were significantly smaller in eyes with a reduced VD of the SCP and DCP in the NPDR group (P < .05). The correlation coefficients were higher for the OP implicit times than for the ΣOP amplitudes in the non-DR group.
conclusionsThe OPs of the focal macular ERG are smaller with prolonged implicit times in association with capillary loss in the macula of diabetic patients. The implicit times are the most sensitive functional parameter that reflects the early changes of the microvasculature in the macula caused by diabetes.
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