Evidence map›Paper›PMID 33173926›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Characterization of a COPD-Associated

Aabida Saferali, Zhonghui Xu, Gloria M Sheynkman, Craig P Hersh, Michael H Cho, Edwin K Silverman, Alain Laederach, Christopher Vollmers, Peter J Castaldi

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Aabida Saferali
Zhonghui Xu
Gloria M Sheynkman
Edwin K Silverman
Alain Laederach
Christopher Vollmers
Peter J Castaldi
Brigham and Women's Hospital · USOffice of Public Health Genomics · USUniversity of California, Santa Cruz · USUniversity of North Carolina at Chapel Hill · US

Funding

Realizing the potential of long-read sequencing technologyR35GM133569 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Christopher Vollmers · 2019 to 2026
$3.4M
Integrative 'Omics of Transcriptome Complexity in COPDK01HL157613 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAFERALI, AABIDA · 2021 to 2025
$944k
NHLBI NIH HHS K01 HL157613NIGMS NIH HHS R35 GM133569
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. Genome-wide association studies (GWAS) have identified over 80 loci that are associated with COPD and emphysema, however for most of these loci the causal variant and gene are unknown. Here, we utilize lung splice quantitative trait loci (sQTL) data from the Genotype-Tissue Expression project (GTEx) and short read sequencing data from the Lung Tissue Research Consortium (LTRC) to characterize a locus in nephronectin (

Identifiers

PMID33173926
PMCPMC7654922
OpenAlexW3094035009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.