Evidence map›Paper›PMID 33173903›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.

Renée Mg Verdiesen, Yvonne T van der Schouw, Carla H van Gils, Wm Monique Verschuren, Frank Jm Broekmans, Maria C Borges, Ana Lg Soares, Deborah A Lawlor, A Heather Eliassen, Peter Kraft and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 3 countries.

Renée Mg VerdiesenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, PO Box 85500, 3508 GA, The Netherlands.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, PO Box 85500, 3508 GA, The Netherlands.
Carla H van GilsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, PO Box 85500, 3508 GA, The Netherlands.
Wm Monique VerschurenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, PO Box 85500, 3508 GA, The Netherlands.
Frank Jm BroekmansDepartment of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Maria C BorgesMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
Ana Lg SoaresMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, 02115, USA.
Peter KraftDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston MA, 02115, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, 27709, USA.
Sioban D HarlowDepartment of Epidemiology, University of Michigan, Michigan, 48109-2029, USA.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Michigan, 48109-2029, USA.
Nanette SantoroDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Colorado, 80045, USA.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
Anna MurrayUniversity of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Katherine S RuthUniversity of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, PO Box 85500, 3508 GA, The Netherlands.
Utrecht University · NLUniversity of Bristol · GBInstitute of Cancer Research · GBUniversity of Exeter · GBUniversity of Michigan · USBrigham and Women's Hospital · USHarvard University · USNational Institute of Environmental Health Sciences · USUniversity of Colorado Denver · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
SWAN Repository IVU01AG017719 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2000 to 2020
$25.0M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
Intramural NIH HHS Z01 ES044005Medical Research Council G1001357Medical Research Council MC_UU_00011/6NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA172726NCI NIH HHS R01 CA178949NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA186107NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U01 AG017719NIA NIH HHS U19 AG063720NINR NIH HHS U01 NR004061Wellcome Trust
6 · The paper itself

Abstract

Anti-Müllerian hormone (AMH) is expressed by antral stage ovarian follicles in women. Consequently, circulating AMH levels are detectable until menopause. Variation in age-specific AMH levels has been associated with breast cancer and polycystic ovary syndrome (PCOS), amongst other diseases. Identification of genetic variants underlying variation in AMH levels could provide clues about the physiological mechanisms that explain these AMH-disease associations. To date, only one variant in

Identifiers

PMID33173903
PMCPMC7654897
OpenAlexW3097456500

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.