ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
The Coppery Age: Copper (Cu)-Involved Nanotheranostics.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 223 citations in OpenAlex.
- Spatiotemporally responsive hybrid hydrogels for sequential therapy and visualized monitoring of multidrug-resistant bacterial wound infections.Bioactive materials · 2026Article
- Recyclable Green Synthesis of CuAngewandte Chemie (International ed. in English) · 2026Article
- Copper-Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids.Advanced healthcare materials · 2026Article
- Engineering Dimensional Configuration of Single-Atom S-Cu-S Sites as Reversible Electron Station for Enhanced Peroxidase-Mimicking.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Engineered anti-cancer nanomedicine for synergistic cuproptosis-immunotherapy.Materials today. Bio · 2025Review
- Real-Time Wireless Detection of Heavy Metal Ions Using a Self-Powered Triboelectric Nanosensor Integrated with an Autonomous Thermoelectric Generator-Powered Robotic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy.Materials today. Bio · 2025Article
- Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses.Bioactive materials · 2025Article
- Controllable Fabrication of ZnO Nanorod Arrays on the Surface of Titanium Material and Their Antibacterial and Anti-Adhesion Properties.Materials (Basel, Switzerland) · 2025Article
- Adhesive micro-liquid for efficient removal of bacterial biofilm infection.Materials today. Bio · 2025Article
- Group IB Metal-Based Nanomaterials for Antibacterial Applications.Small science · 2025Review
- Enhancement of adipose stem cell quality via Cu-MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells.FASEB bioAdvances · 2025Article
- Recent Trends in Biomedical Applications of CuInternational journal of nanomedicine · 2025Review
- Nanomaterials engineered for photothermal therapy in neural tumors and neurodegenerative diseases: biomaterial design, clinical mechanisms and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Strategies to combat cancer drug resistance: focus on copper metabolism and cuproptosis.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Cuproptosis: a promising new target for breast cancer therapy.Cancer cell international · 2024Review
- The Pattern of Copper Release in Copper-Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models.Small science · 2024Article
- Understanding Macrophage Interaction with Antimony-Doped Tin Oxide Plasmonic Nanoparticles.Cells · 2024Article
- Approaches to scarless burn wound healing: application of 3D printed skin substitutes with dual properties of anti-infection and balancing wound hydration levels.EBioMedicine · 2024Article
- Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing.Bioactive materials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu-involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu-composed nanoparticles. Based on the very-recent significant progresses of Cu-involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu-composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu-based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the "Copper Age," these Cu-involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.