Evidence map›Paper›PMID 33173703›Full record

ArticlePlastic and reconstructive surgery. Global open2020

Cortical Thickness in Crouzon-Pfeiffer Syndrome: Findings in Relation to Primary Cranial Vault Expansion.

Alexander T Wilson, Catherine A de Planque, Sumin S Yang, Robert C Tasker, Marie-Lise C van Veelen, Marjolein H G Dremmen, Henri A Vrooman, Irene M J Mathijssen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Cerebral cortex maldevelopment in syndromic craniosynostosis.Developmental medicine and child neurology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander T WilsonDepartment of Plastic and Reconstructive and Hand Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Catherine A de PlanqueDepartment of Plastic and Reconstructive and Hand Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Sumin S YangDepartment of Plastic and Reconstructive and Hand Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Robert C TaskerDepartment of Neurology, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital; Harvard Medical School, Boston, Mass.
Marie-Lise C van VeelenDepartment of Neurological Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Marjolein H G DremmenDepartment of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Henri A VroomanDepartment of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Irene M J MathijssenDepartment of Plastic and Reconstructive and Hand Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpisodes of intracranial hypertension are associated with reductions in cerebral cortical thickness (CT) in syndromic craniosynostosis. Here we focus on Crouzon-Pfeiffer syndrome patients to measure CT and evaluate associations with type of primary cranial vault expansion and synostosis pattern.

methodsRecords from 34 Crouzon-Pfeiffer patients were reviewed along with MRI data on CT and intracranial volume to examine associations. Patients were grouped according to initial cranial vault expansion (frontal/occipital). Data were analyzed by multiple linear regression controlled for age and brain volume to determine an association between global/lobar CT and vault expansion type. Synostosis pattern effect sizes on global/lobar CT were calculated as secondary outcomes.

resultsOccipital expansion patients demonstrated 0.02 mm thicker cortex globally (

conclusionsBoth frontal and occipital primary cranial vault expansions correlate to similar regional CT in Crouzon-Pfeiffer patients. Lambdoid synostosis appears to be associated with cortical thinning, particularly in the cingulate gyri.

Identifiers

PMID33173703
PMCPMC7647527
OpenAlexW3104971732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.