Evidence map›Paper›PMID 33173603›Full record

ArticleActa naturae

Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives.

M P Paramonova, A L Khandazhinskaya, A A Ozerov, S N Kochetkov, R Snoeck, G Andrei, M S Novikov

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

M P ParamonovaDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.
A L KhandazhinskayaEngelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia.
A A OzerovDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.
S N KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia.
R SnoeckRega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
G AndreiRega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
M S NovikovDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.
Volgograd State Medical University · RUEngelhardt Institute of Molecular Biology · RUKU Leuven · BERega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.

Indexed as

4-oxoquinazolineantiviral activityhuman cytomegalovirussynthesisuracil derivativesvaricella zoster virus

Identifiers

PMID33173603
PMCPMC7604896
OpenAlexW3095740614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.