Evidence map›Paper›PMID 33173457›Full record

ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2020

Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms.

Brigitte K Flesch, Angelika Reil, Núria Nogués, Carme Canals, Peter Bugert, Torsten J Schulze, Elly Huiskes, Leendert Porcelijn, Petter Höglund, Paul Ratcliffe and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. TheInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 6 countries.

Brigitte K FleschGerman Red Cross Blood Service Rhineland-Palatinate and Saarland, Bad Kreuznach, Germany.
Angelika ReilGerman Red Cross Blood Service West, Hagen, Germany.
Núria NoguésImmunohematology Laboratory, Blood and Tissue Bank, Barcelona, Spain.
Carme CanalsImmunohematology Laboratory, Blood and Tissue Bank, Barcelona, Spain.
Peter BugertInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Hessen gGmbH, Mannheim, Germany.
Torsten J SchulzeInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Hessen gGmbH, Mannheim, Germany.
Elly HuiskesDepartment of Immunohematology Diagnostics, Sanquin, Amsterdam, The Netherlands.
Leendert PorcelijnDepartment of Immunohematology Diagnostics, Sanquin, Amsterdam, The Netherlands.
Petter HöglundCenter for Hematology and Regenerative Medicine, Karolinska University Hospital, Stockholm, Sweden.
Paul RatcliffeCenter for Hematology and Regenerative Medicine, Karolinska University Hospital, Stockholm, Sweden.
Marlies SchönbacherDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Hans KerchromCentre Hospitalier Universitaire de Nantes, Nantes, France.
Josina KellershohnInstitute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany.
Behnaz BayatInstitute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany.
Banc de Sang i Teixits · ESGerman Red Cross · DEHeidelberg University · DEJustus-Liebig-Universität Gießen · DEKarolinska University Hospital · SESanquin · NLCentre Hospitalier Universitaire de Nantes · FRMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe human neutrophil antigen 2 (HNA-2), which is expressed on CD177, is undetectable in 3-5% of the normal population. Exposure of these HNA-2 STUDY

designAn international collaboration was conducted on the genetic analysis of HNA-2-phenotyped blood samples, including HNA-2-deficient individuals, mothers, and the respective children with neonatal immune neutropenia and regular blood donors.

resultsFrom a total of 54 HNA-2

conclusionThis comprehensive study clearly demonstrates the impact of single nucleotide polymorphisms on the expression of HNA-2 on the neutrophil surface but challenges the hypothesis of regulatory epigenetic effects being implicated in the bimodal CD177 expression pattern.

Indexed as

Human neutrophil antigensMolecular analysisMonoallelic expressionNeutropenia

Identifiers

PMID33173457
PMCPMC7590758
OpenAlexW3002715285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.