ReviewTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2020
RBC Transfusion Triggers: Is There Anything New?
Review in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Recommendations for implementing patient blood management-an updated modified Delphi consensus from a multidisciplinary expert panel in Hong Kong.Journal of anesthesia, analgesia and critical care · 2026Review
- The Effect of Donor Packed Cell Volume and Storage Characteristics on Transfusion Efficacy in Cats.Veterinary medicine (Auckland, N.Z.) · 2026Article
- Machine learning for the prediction of blood transfusion risk during or after mitral valve surgery: a multicenter retrospective cohort study.Scientific reports · 2025Article
- Pitfalls of reasoning in hospital-based transfusion medicine.Transfusion medicine (Oxford, England) · 2024Review
- Red blood cell transfusion for critically ill patients admitted through the emergency department in South Korea.Acute and critical care · 2024Article
- Patient Blood Management Program Implementation: Comprehensive Recommendations and Practical Strategies.Brazilian journal of cardiovascular surgery · 2024Review
- Incidence, risk factors and impact of anemia after elective neurosurgery: A retrospective cohort study.World neurosurgery: X · 2024Article
- Alternative blood transfusion triggers: a narrative review.BMC anesthesiology · 2024Review
- Patient Blood Management in Microsurgical Procedures for Reconstructive Surgery.Diagnostics (Basel, Switzerland) · 2023Article
- Current Status of Measurement Accuracy for Total Hemoglobin Concentration in the Clinical Context.Biosensors · 2022Article
- The Limits of Acute Anemia.Journal of clinical medicine · 2022Review
- Coagulation and Transfusion Updates From 2021.Journal of cardiothoracic and vascular anesthesia · 2022Review
- Association between Anemia and New-Onset Atrial Fibrillation in Critically Ill Patients in the Intensive Care Unit: A Retrospective Cohort Analysis.Clinics and practice · 2022Article
- The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine.Molecular aspects of medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years, in daily clinical practice, the traditional 10/30 rule (hemoglobin 10 g/dL - hematocrit 30%) has been the most commonly used trigger for blood transfusions. Over the years, this approach is believed to have contributed to a countless number of unnecessary transfusions and an unknown number of overtransfusion-related deaths. Recent studies have shown that lower hemoglobin levels can safely be accepted, even in critically ill patients. However, even these new transfusion thresholds are far beyond the theoretical limits of individual anemia tolerance. For this reason, almost all publications addressing the limits of acute anemia recommend physiological transfusion triggers to indicate the transfusion of erythrocyte concentrates as an alternative. Although this concept appears intuitive at first glance, no solid scientific evidence supports the safety and benefit of physiological transfusion triggers to indicate the optimal time point for transfusion of allogeneic blood. It is therefore imperative to continue searching for the most sensitive and specific parameters that can guide the clinician when to transfuse in order to avoid anemia-induced organ dysfunction while avoiding overtransfusion-related adverse effects. This narrative review discusses the concept of anemia tolerance and critically compares hemoglobin-based triggers with physiological transfusion for various clinical indications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.