Evidence map›Paper›PMID 33173294›Full record

ArticleInternational journal of nanomedicine2020

Noninvasive Molecular Imaging of the Enhanced Permeability and Retention Effect by

Betina Børresen, Anders Elias Hansen, Frederikke Petrine Fliedner, Jonas Rosager Henriksen, Dennis Ringkjøbing Elema, Malene Brandt-Larsen, Lotte Kellemann Kristensen, Annemarie Thuri Kristensen, Thomas Lars Andresen, Andreas Kjær

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. A quantitative MRI-based approach to estimate the permeation and retention of nanomedicines in tumors.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Liposomes: Biomedical Applications.Chonnam medical journal · 2021
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Betina BørresenDepartment of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 1870, Denmark.
Anders Elias HansenCluster for Molecular Imaging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N 2200, Denmark.
Frederikke Petrine FliednerCluster for Molecular Imaging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N 2200, Denmark.
Jonas Rosager HenriksenDTU Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Lyngby, Kgs 2800, Denmark.
Dennis Ringkjøbing ElemaDTU Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Lyngby, Kgs 2800, Denmark.ORCID 0000-0002-4009-6727
Malene Brandt-LarsenDepartment of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen Ø 2100, Denmark.
Lotte Kellemann KristensenCluster for Molecular Imaging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N 2200, Denmark.
Annemarie Thuri KristensenDepartment of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 1870, Denmark.
Thomas Lars AndresenDTU Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Lyngby, Kgs 2800, Denmark.
Andreas KjærCluster for Molecular Imaging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N 2200, Denmark.
University of Copenhagen · DKTechnical University of Denmark · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe accumulation of liposome encapsulated chemotherapy in solid cancers is dependent on the presence of the enhanced permeability and retention (EPR) effect. Positron emission tomography (PET) imaging with a liposome encapsulated radioisotope, such as liposome encapsulated Cu-64 ( MATERIALS AND

methodsTo increase our understanding of EPR variations and to ultimately identify an alternative marker for the EPR effect, we investigated the correlation between

results

Indexed as

AnimalsCell Line, TumorColorectal NeoplasmsContrast MediaCopper RadioisotopesDiffusionFemaleFluorodeoxyglucose F18Gallium RadioisotopesHumansLiposomesMagnetic Resonance ImagingMice, Inbred BALB CMolecular ImagingNeoplasmsNeovascularization, Pathologicarginyl-glycyl-aspartic acidContrast MediaCopper-64Copper RadioisotopesFluorodeoxyglucose F18Gallium-68Gallium RadioisotopesLiposomesOligopeptidesRadiopharmaceuticalsEPR effectliposomeneoangiogenesispositron emission tomography

Identifiers

PMID33173294
PMCPMC7646401
OpenAlexW3096535406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.