Evidence map›Paper›PMID 33173290›Full record

ArticleInternational journal of nanomedicine2020

Mycogenic Synthesis of Extracellular Zinc Oxide Nanoparticles from

Basavaraju Sumanth, Thimappa Ramachandrappa Lakshmeesha, Mohammad Azam Ansari, Mohammad A Alzohairy, Arakere Chunchegowda Udayashankar, Balagangadharaswamy Shobha, Siddapura Ramachandrappa Niranjana, Chowdappa Srinivas, Ahmad Almatroudi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 134 citations in OpenAlex.

  1. Review
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  5. Evaluation of Anticancer Potential in Human Colorectal CarcinomaAnti-cancer agents in medicinal chemistry · 2026
    Article
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  7. Article
  8. Article
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  10. Review
  11. Review
  12. Synthesis of zinc oxide nanoparticles usingFrontiers in microbiology · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Green Synthesis of Zinc Oxide Nanoparticles fromInternational journal of nanomedicine · 2024
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Basavaraju Sumanth *Department of Microbiology & Biotechnology, Jnana Bharathi Campus, Bangalore University, Bangalore 560056, India.ORCID 0000-0001-5196-9792
Thimappa Ramachandrappa Lakshmeesha *Department of Microbiology & Biotechnology, Jnana Bharathi Campus, Bangalore University, Bangalore 560056, India.
Mohammad Azam AnsariDepartment of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahaman Bin Faisal University, Dammam 31441, Saudi Arabia.
Mohammad A AlzohairyDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Saudi Arabia.
Arakere Chunchegowda UdayashankarDepartment of Studies in Biotechnology, University of Mysore, Mysuru 570006, India.
Balagangadharaswamy ShobhaDepartment of Microbiology & Biotechnology, Jnana Bharathi Campus, Bangalore University, Bangalore 560056, India.
Siddapura Ramachandrappa NiranjanaDepartment of Studies in Biotechnology, University of Mysore, Mysuru 570006, India.
Chowdappa Srinivas *Department of Microbiology & Biotechnology, Jnana Bharathi Campus, Bangalore University, Bangalore 560056, India.ORCID 0000-0002-5800-7163
Ahmad AlmatroudiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Saudi Arabia.ORCID 0000-0002-1491-6402
Bangalore University · INQassim University · SAUniversity of Mysore · INImam Abdulrahman Bin Faisal University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study aimed to find an effective method for fungal-mediated synthesis of zinc oxide nanoparticles using endophytic fungal extracts and to evaluate the efficiency of synthesized ZnO NPs as antimicrobial and anticancerous agents.

methodsZinc oxide nanoparticles (ZnO NPs) were produced from zinc nitrate hexahydrate with fungal filtrate by the combustion method. The spectroscopy and microscopy techniques, such as ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), and transmission electron microscopy (TEM) with selected area electron diffraction (SAED), were used to characterize the obtained product. Antibacterial activity on Gram-positive (

resultsThe fungal synthesized ZnO NPs were pure, mainly hexagonal in shape and size range of 34-55 nm. The biosynthesized ZnO NPs could proficiently inhibit both Gram-positive and Gram-negative bacteria. ZnO NPs synthesized from fungal extract exhibited antifungal activity in a dose-dependent manner with a high percentage of mycelial inhibition. The cell uptake analysis of ZnO NPs suggests that a significant amount of ZnO NPs (1 μg/mL) was internalized without disturbing cancer cells' morphology. As a result, the synthesized ZnO NPs showed significant anticancer activity against cancer cells at 1 μg/mL concentration.

conclusionThis fungus-mediated synthesis of ZnO NPs is a simple, eco-friendly, and non-toxic method. Our results show that the synthesized ZnO NPs are an excellent novel antimicrobial and anticancer agent. Further studies are required to understand the mechanism of the antimicrobial, anticancerous action of ZnO NPs and their possible genotoxicity.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAntineoplastic AgentsAscomycotaCell Line, TumorGram-Negative BacteriaGram-Positive BacteriaHumansLamialesMetal NanoparticlesMicrobial Sensitivity TestsMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionPlant LeavesSpectrometry, X-Ray EmissionSpectroscopy, Fourier Transform InfraredAnti-Bacterial AgentsAntifungal AgentsAntineoplastic AgentsZinc Oxideantibacterialanticancerousantifungalendophytic fungizinc oxide nanoparticles

Identifiers

PMID33173290
PMCPMC7646447
OpenAlexW3095179349

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.