ArticleMolecular psychiatry2021
Predicting the course of ADHD symptoms through the integration of childhood genomic, neural, and cognitive features.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- Predicting ADHD in Children and Adolescents With Artificial Intelligence: A Scoping Review of Common Models.Health science reports · 2025Article
- Fluctuating course of attention-deficit/hyperactivity disorder across development: Multifactorial influences.World journal of psychiatry · 2025Review
- Machine learning in attention-deficit/hyperactivity disorder: new approaches toward understanding the neural mechanisms.Translational psychiatry · 2023Review
- Longitudinal trajectories of childhood and adolescent attention deficit hyperactivity disorder diagnoses in three cohorts.EClinicalMedicine · 2023Article
- The Oregon ADHD-1000: A new longitudinal data resource enriched for clinical cases and multiple levels of analysis.Developmental cognitive neuroscience · 2023Article
- Evidence from "big data" for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Investigation of white matter functional networks underlying different behavioral profiles in attention-deficit/hyperactivity disorder.Psychoradiology · 2022Article
- Is genetic risk of ADHD mediated via dopaminergic mechanism? A study of functional connectivity in ADHD and pharmacologically challenged healthy volunteers with a genetic risk profile.Translational psychiatry · 2022Article
- Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan.Frontiers in human neuroscience · 2022Review
- A Longitudinal Study of Resting-State Connectivity and Response to Psychostimulant Treatment in ADHD.The American journal of psychiatry · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
Childhood attention deficit hyperactivity disorder (ADHD) shows a highly variable course with age: some individuals show improving, others stable or worsening symptoms. The ability to predict symptom course could help individualize treatment and guide interventions. By studying a cohort of 362 youth, we ask if polygenic risk for ADHD, combined with baseline neural and cognitive features could aid in the prediction of the course of symptoms over an average period of 4.8 years. Compared to a never-affected comparison group, we find that participants with worsening symptoms carried the highest polygenic risk for ADHD, followed by those with stable symptoms, then those whose symptoms improved. Participants with worsening symptoms also showed atypical baseline cognition. Atypical microstructure of the cingulum bundle and anterior thalamic radiation was associated with improving symptoms while reduction of thalamic volume was found in those with stable symptoms. Machine-learning algorithms, trained and tested on independent groups, performed well in classifying those never affected against groups with worsening, stable, and improving symptoms (area under the curve >0.79). We conclude that some measures of polygenic risk, cognition, and neuroimaging show significant associations with the future course of ADHD symptoms and may have modest predictive power. These features warrant further exploration as prognostic tools.
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