Evidence map›Paper›PMID 33173193›Full record

ArticleMolecular psychiatry2021

Altered neurochemistry in the anterior white matter of bipolar children and adolescents: a multivoxel

Jonika Tannous, Bo Cao, Jeffrey A Stanley, Giovana B Zunta-Soares, Benson Mwangi, Marsal Sanches, Jair C Soares

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Reduced prefrontal total choline MRS levels characterize the neurodevelopmental phenotype of bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jonika Tannous *UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA. jonika.d.tannous@gmail.com.ORCID http://orcid.org/0000-0003-4022-9267
Bo Cao *Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-3401-6900
Jeffrey A StanleyDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Wayne State University, Detroit, MI, USA.
Giovana B Zunta-SoaresUT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA.
Benson MwangiUT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA.
Marsal SanchesUT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA.
Jair C SoaresUT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA.
The University of Texas Health Science Center · USUniversity of Alberta · CAWayne State University · US

Funding

Searching for Endophenotypes of Bipolar DisorderR01MH085667 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SOARES, JAIR C · 2012 to 2016
$3.0M
Fronto-Limbic Brain of Bipolar Children and AdolescentsR01MH069774 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNGSTROM, ERIC · 2005 to 2008
$1.9M
NIMH NIH HHS R01 MH069774NIMH NIH HHS R01 MH085667
6 · The paper itself

Abstract

Abnormalities within frontal lobe gray and white matter of bipolar disorder (BD) patients have been consistently reported in adult and pediatric studies, yet little is known about the neurochemistry of the anterior white matter (AWM) in pediatric BD and how medication status may affect it. The present cross-sectional 3T

Indexed as

Bipolar DisorderNeurochemistryWhite MatterAdolescentAdultChildCross-Sectional StudiesHumansProton Magnetic Resonance Spectroscopy

Identifiers

PMID33173193
PMCPMC8664279
OpenAlexW3105715936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.