ArticleScientific reports2020
Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- High-sensitivity Raman spectroscopy for prostate cancer detection and tissue extraction guidance.Biomedical optics express · 2026Article
- Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy - a cadaveric study.Biomedical optics express · 2026Article
- Raman Spectroscopy Detects Bone Mineral Changes with Aging in Archaeological Human Lumbar Vertebrae from Thornton Abbey.Applied spectroscopy · 2025Article
- Raman Spectroscopy in Cellular and Tissue Aging Research.Aging cell · 2025Review
- Qualitative comparison of decalcifiers for mouse bone cryosections for subsequent biophotonic analysis.Scientific reports · 2025Article
- Raman Microscopy and Bone.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Harnessing Raman spectroscopy and multimodal imaging of cartilage for osteoarthritis diagnosis.Scientific reports · 2024Article
- Nutrition and Bone Marrow Adiposity in Relation to Bone Health.Physiological research · 2024Review
- Differences in whole blood before and after hemodialysis session of subjects with chronic kidney disease measured by Raman spectroscopy.Lasers in medical science · 2024Article
- Article
- Article
- Long-Term Fate and Efficacy of a Biomimetic (Sr)-Apatite-Coated Carbon Patch Used for Bone Reconstruction.Journal of functional biomaterials · 2023Article
- Article
- Chronological Age Estimation of Male Occipital Bone Based on FTIR and Raman Microspectroscopy.Bioinorganic chemistry and applications · 2022Article
- Maturation of biomimetic hydroxyapatite in physiological fluids: a physicochemical and proteomic study.Materials today. Bio · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone strength in human cortical bone is determined by the composition and structure of both the mineral and collagen matrices and influenced by factors such as age, gender, health, lifestyle and genetic factors. Age-related changes in the bone matrix are known to result in loss of mechanical strength and increased fragility. In this study we show how Raman spectroscopy, with its exquisite sensitivity to the molecular structure of bone, reveals new insights into age- and sex-related differences. Raman analysis of 18 samples of cortical hip bone obtained from people aged between 47-82 years with osteoarthritis (OA) found subtle changes in the lipid and collagen secondary structure, and the carbonate (CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.