Trial reportScientific reports2020
Body mass index and body weight change during adjuvant chemotherapy in colon cancer patients: results from the AVANT trial.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Colorectal cancer patients' outcome in correlation with dietary and nutritional status: a systematic review.Annals of medicine · 2023Pooled it
- Association of patient factors and health-related quality of life with weight changes during chemotherapy for colorectal cancer: secondary analysis of the SCOT trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Asynchronous Recovery of Body Composition After Curative Surgery for Gastric and Colorectal Cancer: A Prospective Longitudinal Study.Nutrients · 2026Article
- Does Cachexia Matter for Glioblastoma Multiforme?Cancers · 2026Article
- Association between weight loss and survival outcomes in patients with colorectal cancer: a meta-analysis.Discover oncology · 2025Review
- Weight Management Experiences Among People Affected by Overweight and Obesity Who Are Living With and Beyond Colorectal, Breast or Prostate Cancer: A Cross-Sectional Survey.Cancer medicine · 2025Article
- Patient-Reported Outcomes and Body Composition Changes in Patients With Colorectal Cancer During Chemotherapy: A Longitudinal Study.Journal of nursing management · 2025Article
- The Impact of Pre-Chemotherapy Body Composition and Immunonutritional Markers on Chemotherapy Adherence in Stage III Colorectal Cancer Patients.Journal of clinical medicine · 2023Article
- Article
- Geriatric functional assessment for decision-making on adjuvant chemotherapy in older colon cancer patients.The Korean journal of internal medicine · 2022Article
- Impact of Obesity on Quality of Life, Psychological Distress, and Coping on Patients with Colon Cancer.The oncologist · 2021Observational
- Key biomarkers within the colorectal cancer related inflammatory microenvironment.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While obesity increases colorectal cancer incidence, there are inconsistent results in the prognostic role of obesity or body weight change on survival. This study investigated the prognostic impact of body weight and weight change in stage III or high risk stage II colon cancer patients. We used data from patients enrolled in the phase III AVANT trial. The AVANT trial investigated the efficacy of adding bevacizumab to standard adjuvant chemotherapy (FOFOX or XELOX). Weight change during the first 6 months of adjuvant chemotherapy was measured. Cox proportional hazard model was used to assess the prognostic influence of body weight and weight change. Among 3451 intention-to-treat population, body weight and weight change was measured in 3449 (99.9%) and 2455 (71.1%) patients, respectively. Among 2455 patients, 651 (26.5%) had weight gain over 5 kg and 179 (7.3%) had weight loss over 5 kg. Weight gain was more frequently observed in Asian and male. Neither baseline BMI nor weight change affected recurrence or survival in the Cox proportional hazard model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.