Evidence map›Paper›PMID 33173143›Full record

ArticleScientific reports2020

Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival.

Jiajia Liu, Weiming Zhu, Zhexuan Li, Gengming Cai, Juncheng Wang, Qinglai Tang, Christopher A Maroun, Gangcai Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Jiajia LiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410010, China.
Weiming ZhuFuzhou Medical College of Nanchang University, Fuzhou, 344000, China.
Zhexuan LiDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, 410008, China.
Gengming CaiDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Quanzhou, Fujian Medical University, Quanzhou, 362000, China.
Juncheng WangDepartment of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, 410008, China.
Qinglai TangDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410010, China.
Christopher A MarounDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, 21287, USA.
Gangcai ZhuDepartment of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410010, China. qianhudoctor@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CNFujian Medical University · CNFuzhou University · CNJohns Hopkins University · USSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The link between differences in molecular expression and survival among advanced laryngeal (LSCC) and hypopharyngeal squamous carcinoma (HPSCC) remains unclear. Here, we applied the Surveillance, Epidemiology, and End Results (SEER) program, Isobaric tag for relative and absolute quantitation (iTRAQ) with Liquid chromatography-mass spectrometry (LC-MS/MS) proteomics data and The Cancer Genome Atlas (TCGA) related data to discover the possible disparities between HPSCC and LSCC. Our results showed a significantly worse 5-year overall-survival in HPSCC compared with LSCC before and after adjusting for clinical parameters. 240 differentially expressed proteins were enriched in molecular networks of cytoskeleton remodeling and antigen presentation. Moreover, HPSCC consisted of less T-central-memory cells, T-follicular-helper cells, TGF-β response, and CD4

Indexed as

Gene Expression Regulation, NeoplasticAgedBiomarkers, TumorCarcinoma, Squamous CellChromatography, LiquidFemaleGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansHypopharyngeal NeoplasmsKaplan-Meier EstimateLaryngeal NeoplasmsMaleMiddle AgedNeoplasm StagingBiomarkers, Tumor

Identifiers

PMID33173143
PMCPMC7655956
OpenAlexW3106287873

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.