ArticleScientific reports2020
Expression of Dux family genes in early preimplantation embryos.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Role of CEBPa in trophectoderm competence installment.Science advances · 2025Article
- The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus.Nature reviews. Genetics · 2025Review
- A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit.Communications biology · 2024Article
- H3.1/3.2 regulate the initial progression of the gene expression program.Nucleic acids research · 2024Article
- Review
- DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers.eLife · 2024Article
- A maternal-effectGenes & development · 2024Article
- The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation.International journal of molecular sciences · 2024Review
- DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers.bioRxiv : the preprint server for biology · 2023Article
- Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development.Genes & development · 2023Article
- The physiological and pathological mechanisms of early embryonic development.Fundamental research · 2022Review
- Zygotic gene activation in mice: profile and regulation.The Journal of reproduction and development · 2022Review
- DUX: One Transcription Factor Controls 2-Cell-like Fate.International journal of molecular sciences · 2022Review
- The regulation of totipotency transcription: Perspective fromFrontiers in cell and developmental biology · 2022Review
- Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development.Journal of assisted reproduction and genetics · 2021Article
- Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X.The Journal of reproduction and development · 2021Article
- Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency.Biomolecules · 2021Review
- Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems.Stem cells international · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After fertilization, the zygotic genome is activated through two phases, minor zygotic activation (ZGA) and major ZGA. Recently, it was suggested that DUX is expressed during minor ZGA and activates some genes during major ZGA. However, it has not been proven that Dux is expressed during minor ZGA and functions to activate major ZGA genes, because there are several Dux paralogs that may be expressed in zygotes instead of Dux. In this study, we found that more than a dozen Dux paralogs, as well as Dux, are expressed during minor ZGA. Overexpression of some of these genes induced increased expression of major ZGA genes. These results suggest that multiple Dux paralogs are expressed to ensure a sufficient amount of functional Dux and its paralogs which are generated during a short period of minor ZGA with a low transcriptional activity. The mechanism by which multiple Dux paralogs are expressed is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.