ArticleScientific reports2020
The burden of childhood hand-foot-mouth disease morbidity attributable to relative humidity: a multicity study in the Sichuan Basin, China.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Historical evolution, research hotspots and emerging trends of pediatric hand, foot, and mouth disease: a bibliometric worldview since the 21st century.Frontiers in medicine · 2025Pooled it
- Analysis of Spatiotemporal Risks of Environmental Driving Factors of Respiratory Diseases.GeoHealth · 2026Article
- Short-term effects of meteorological factors on hand, foot, and mouth disease in Zhengzhou, China.Scientific reports · 2026Article
- Impact of precipitation patterns on the risk of hand, foot, and mouth disease in Southwest China: insight from a disease burden perspective.BMC public health · 2025Article
- Bayesian joint spatiotemporal modelling of primary infection and reinfection of HFMD at county level in Jiangsu, China, 2009-2023.BMC public health · 2025Article
- Impact of meteorological factors on the incidence of hand, foot and mouth disease in Ningbo from 2014 to 2019: a causal convolutional neural networks.BMC public health · 2025Article
- Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021.Infectious medicine · 2024Article
- Article
- How multiple air pollutants affect hand, foot, and mouth disease incidence in children: assessing effect modification by geographical context in multicity of Sichuan, southwest China.BMC public health · 2024Article
- Healthcare Policies to Eliminate Neglected Tropical Diseases (NTDs) in India: A Roadmap.International journal of environmental research and public health · 2023Review
- Influence of social and meteorological factors on hand, foot, and mouth disease in Sichuan Province.BMC public health · 2023Article
- Combined impacts of environmental and socioeconomic covariates on HFMD risk in China: A spatiotemporal heterogeneous perspective.PLoS neglected tropical diseases · 2023Article
- Assessing the impact of ambient temperature on the risk of hand, foot, and mouth disease in Guangdong, China: New insight from the disease severity and burden.PLoS neglected tropical diseases · 2022Article
- Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.BMC public health · 2022Article
- Spatial and Temporal Characteristics of Hand-Foot-and-Mouth Disease and Their Influencing Factors in Urumqi, China.International journal of environmental research and public health · 2021Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand, foot and mouth disease (HFMD) is a growing threat to children's health, causing a serious public health burden in China. The relationships between associated meteorological factors and HFMD have been widely studied. However, the HFMD burden due to relative humidity from the perspective of attributable risk has been neglected. This study investigated the humidity-HFMD relationship in three comprehensive perspectives, humidity-HFMD relationship curves, effect modification and attributable risks in the Sichuan Basin between 2011 and 2017. We used multistage analyses composed of distributed lag nonlinear models (DLNMs), a multivariate meta-regression model and the calculations of attributable risk to quantify the humidity-HFMD association. We observed a J-shaped pattern for the pooled cumulative humidity-HFMD relationship, which presented significant heterogeneity relating to the geographical region and number of primary school students. Overall, 27.77% (95% CI 25.24-30.02%) of HFMD infections were attributed to humidity. High relative humidity resulted in the greatest burden of HFMD infections. The proportion of high humidity-related HFMD in the southern basin was higher than that in the northern basin. The findings provide evidence from multiple perspectives for public health policy formulation and health resource allocation to develop priorities and targeted policies to ease the HFMD burden associated with humidity.
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