ArticleScientific reports2020
Histogram analysis of T2 mapping for detecting early involvement of extraocular muscles in patients with thyroid-associated ophthalmopathy.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Orbital MRI for thyroid eye disease activity staging: a systematic review and meta-analysis.BMC ophthalmology · 2026Pooled it
- The diagnostic performance comparison between T2 mapping and Dixon against the activity of thyroid-associated ophthalmopathy: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- MRI-based automated segmentation and multiparametric quantification for assessing orbital soft tissue involvement in thyroid eye disease.European radiology · 2026Article
- IntegratedEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Multiparametric MRI quantitative metrics for grading and staging graves' ophthalmopathy.BMC medical imaging · 2026Article
- Habitat imaging based on water-fat separation for interpreting extraocular muscle heterogeneity in thyroid eye disease.European thyroid journal · 2026Article
- The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy.Diagnostics (Basel, Switzerland) · 2025Review
- Assessment of disease activity in Graves' orbitopathy.Frontiers in ophthalmology · 2025Review
- Application progress of magnetic resonance imaging in thyroid associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Advancements in imaging research in thyroid-associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Correlation between intraorbital structural alterations and diplopia in thyroid-associated ophthalmopathy: an MRI-based study.American journal of translational research · 2025Article
- Predictive markers for anti-inflammatory treatment response in thyroid eye disease.Frontiers in endocrinology · 2023Review
- Texture analysis of orbital magnetic resonance imaging for monitoring and predicting treatment response to glucocorticoids in patients with thyroid-associated ophthalmopathy.Endocrine connections · 2021Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using histogram analysis of T2 values to detect early involvement of extraocular muscles (EOMs) in patients with thyroid-associated ophthalmopathy (TAO). Five EOMs of each orbit were analyzed for 45 TAO patients and 22 healthy controls (HCs). Patients' EOMs were grouped into involved or normal-appearing EOMs (NAEOMs). Histogram parameters and signal intensity ratios (SIRs) of EOMs were compared; receiver operating characteristic (ROC) curve analysis was performed to differentiate NAEOMs from EOMs of HCs. 24 patients were reassessed following immunosuppressive treatment. For SIRs, involved muscles showed higher values than those of NAEOMs and HCs (p < 0.05); there were no differences between NAEOMs and HCs (p = 0.26). Parameters of involved muscles showed no different from those of NAEOMs excluding 25th, 50th percentiles, and standard deviation (SD) (p < 0.05). NAEOMs displayed higher values of 90th, 95th percentiles, SD, skewness, inhomogeneity, and entropy than HCs (p < 0.05). ROC curve analysis of entropy yielded the best area under the ROC curve (AUC; 0.816) for differentiating NAEOMs and HCs. After treatment, histogram parameters including 5th, 75th, 90th, and 95th percentiles, SD, kurtosis, inhomogeneity, and entropy were reduced in NAEOMs (p < 0.05). T2 histogram analysis could detect early involvement of EOMs in TAO prior to detection on conventional orbital MRI.
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