ArticleScientific reports2020
Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intestinal bacteria trigger a hibernation-like state in homotherms via the gut-brain axis.NPJ biofilms and microbiomes · 2025Article
- Natural Mutation in Naked Mole-Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis.Acta physiologica (Oxford, England) · 2025Article
- Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications.Food science & nutrition · 2025Review
- Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.The EMBO journal · 2023Article
- The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period.Animals : an open access journal from MDPI · 2023Review
- Metabolism, homeostasis, and aging.Trends in endocrinology and metabolism: TEM · 2023Review
- Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization.Frontiers in immunology · 2023Article
- Housing and Husbandry Alternatives for Naked Mole Rat Colonies Used in Research Settings.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1.Nature communications · 2021Article
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold and some non-cold environments. Previous studies suggest that NMR-BAT induces thermogenesis by cold exposure. However, detailed NMR-BAT characteristics and whether NMR-BAT thermogenesis occurs in non-cold environments are unknown. Here, we show beta-3 adrenergic receptor (ADRB3)-dependent thermogenic potential of NMR-BAT, which contributes to thermogenesis in the isolated queen in non-cold environments (30 °C). NMR-BAT expressed several brown adipocyte marker genes and showed noradrenaline-dependent thermogenic activity in vitro and in vivo. Although our ADRB3 inhibition experiments revealed that NMR-BAT thermogenesis slightly delays the decrease in body temperature in a cold environment (20 °C), it was insufficient to prevent the decrease in the body temperatures. Even at 30 °C, NMRs are known to prevent the decrease of and maintain their body temperature by heat-sharing behaviors within the colony. However, isolated NMRs maintained their body temperature at the same level as when they are in the colony. Interestingly, we found that queens, but not subordinates, induce BAT thermogenesis in this condition. Our research provides novel insights into NMR thermoregulation.
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