ArticleScientific reports2020
First sequencing of ancient coral skeletal proteins.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- How Single-Cell Transcriptomics of Hydractinia Is Informing the Evolution of Cnidarian Sensory Systems.Integrative and comparative biology · 2025Review
- Multiomics data integration, limitations, and prospects to reveal the metabolic activity of the coral holobiont.FEMS microbiology ecology · 2024Review
- First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host.Scientific reports · 2023Article
- Comparative transcriptome analysis reveals deep molecular landscapes in stony coralFrontiers in genetics · 2023Article
- Article
- A primer for ZooMS applications in archaeology.Proceedings of the National Academy of Sciences of the United States of America · 2022Review
- The spatial network of skeletal proteins in a stony coral.Journal of the Royal Society, Interface · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Here we report the first recovery, sequencing, and identification of fossil biomineral proteins from a Pleistocene fossil invertebrate, the stony coral Orbicella annularis. This fossil retains total hydrolysable amino acids of a roughly similar composition to extracts from modern O. annularis skeletons, with the amino acid data rich in Asx (Asp + Asn) and Glx (Glu + Gln) typical of invertebrate skeletal proteins. It also retains several proteins, including a highly acidic protein, also known from modern coral skeletal proteomes that we sequenced by LC-MS/MS over multiple trials in the best-preserved fossil coral specimen. A combination of degradation or amino acid racemization inhibition of trypsin digestion appears to limit greater recovery. Nevertheless, our workflow determines optimal samples for effective sequencing of fossil coral proteins, allowing comparison of modern and fossil invertebrate protein sequences, and will likely lead to further improvements of the methods. Sequencing of endogenous organic molecules in fossil invertebrate biominerals provides an ancient record of composition, potentially clarifying evolutionary changes and biotic responses to paleoenvironments.
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