ArticleNature communications2020
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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89citing papers in PubMed, 1 pooled it
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.Nature communications · 2022Pooled it
- Metabolic Stress Testing Reveals Persistent Lipid-Handling Dysfunction in Women With Polycystic Ovary Syndrome Despite Exercise Training.Diabetes, obesity & metabolism · 2026Trial
- MRMhub: a scalable data-processing framework for large-scale targeted metabolomics.Nature metabolism · 2026Article
- Circulating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer's disease.Molecular psychiatry · 2026Article
- Isomer-Resolved Mass Spectrometry Imaging Reveals Regional and Age-Dependent Glycolipid Metabolism in Rat Brain.ACS central science · 2026Article
- The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.Nature aging · 2026Article
- Interconnected influences of diet, gut microbiome, and metabolome on cognition across three metabolomics platforms.Research square · 2026Article
- A lipidomic based metabolic age score for monitoring the effects of lifestyle and diet on metabolic disease risk.Research square · 2026Article
- A lipidomics roadmap: from basic research to societal challenges.Nature communications · 2026Review
- A multi-tiered workflow for examining organic acid profiles delineates tissue-specific changes in fatty acyl partitioning during aging.Cell reports methods · 2026Article
- Longitudinal Sparse Single-Omics Factor Analysis for High-Dimensional Blood Biomarkers in Alzheimer's Disease.Statistics in medicine · 2026Article
- Plasma lipid trajectories improve prediction of future Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.Lipids in health and disease · 2026Article
- Identification of plasma biomarkers in lipid metabolism for accurate prediction of Alzheimer's disease.Translational psychiatry · 2026Article
- Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies.Sports medicine - open · 2026Article
- Article
- Lipidomic signatures reveal biomarkers of mild cognitive impairment.Translational psychiatry · 2026Article
- Plasma lipidomic fingerprinting enables high-accuracy biomarker discovery for Alzheimer's disease: a targeted LC-MRM/MS approach.GeroScience · 2026Article
- Predicting progression of Alzheimer's disease using blood-based multi-omics data.Bioinformatics advances · 2026Article
- Distinct CSF lipidomic profiles are associated with five proteomic subtypes in patients with Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors.
Kevin HuynhBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0001-6170-2207
Wei Ling Florence LimSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.ORCID 0000-0002-8988-2147
Corey GilesBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Kaushala S JayawardanaBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Agus SalimBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Natalie A MellettBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Adam Alexander T SmithBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Gavriel OlshanskyBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Brian G DrewBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Pratishtha ChatterjeeSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.ORCID 0000-0003-4877-1958
Ian MartinsSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.ORCID 0000-0002-2390-1501
Simon M LawsSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.ORCID 0000-0002-4355-7082
Ashley I BushThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0001-8259-9069
Christopher C RoweThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Victor L VillemagneDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia.
David AmesNational Ageing Research Institute, Parkville, VIC, 3050, Australia.
Colin L MastersThe Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Matthias ArnoldDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.ORCID 0000-0002-4666-0923
Kwangsik NhoDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-1376-8532
Rebecca BaillieRosa & Co LLC, San Carlos, CA, USA.ORCID 0000-0003-3966-6320
Xianlin HanBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-8615-2413
Rima Kaddurah-DaoukDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA. rima.kaddurahdaouk@duke.edu.ORCID 0000-0003-1858-5732
Ralph N MartinsSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia. r.martins@ecu.edu.au.
Peter J MeikleBaker Heart and Diabetes Institute, Melbourne, VIC, Australia. peter.meikle@baker.edu.au.ORCID 0000-0002-2593-4665
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3MMetabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0MOLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINER01CA129769 · NCI · GEORGETOWN UNIVERSITY · PI AHLES, TIM ALAN, MANDELBLATT, JEANNE · 2009 to 2020
$7.3MMemory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9MMetabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type DementiasRF1AG051550 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KLING, MITCHEL ALLAN · 2015 to 2016
$6.3MMetabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9MMetabolic Networks and Pathways in Alzheimer's DiseaseR01AG046171 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F · 2014 to 2017
$4.4MMetabolic Network Analysis of Biochemical Trajectories in Alzheimer's DiseaseRF1AG057452 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2017 to 2017
$3.5MGut Liver Brain Biochemical Axis in Alzheimer's DiseaseRF1AG058942 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, VAN DUIJN, CORNELIA MARJA · 2018 to 2018
$3.4MMulti-Domain Sensory Measures as Biomarkers of Alzheimer's Disease in Preclinical and Prodromal StagesR01AG061788 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI RISACHER, SHANNON L · 2019 to 2023
$3.0MIntegrating Neuroimaging, Multi-omics, and Clinical Data in Complex DiseaseR01LM012535 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2017 to 2021
$1.7MNCI NIH HHS R01 CA129769NIA NIH HHS K01 AG049050NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG046171NIA NIH HHS R01 AG061788NIA NIH HHS R03 AG054936NIA NIH HHS RF1 AG051550NIA NIH HHS RF1 AG057452NIA NIH HHS RF1 AG058942NIA NIH HHS RF1 AG059093NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG061359NLM NIH HHS R01 LM012535
Abstract
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM
Indexed as
LipidomicsAlzheimer DiseaseBiomarkersCohort StudiesComputer SimulationHumansLipid MetabolismLipidsMetabolomicsBiomarkersLipids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.