Evidence map›Paper›PMID 33173004›Full record

ArticlemBio2020

Loss of the Conserved Alveolate Kinase MAPK2 Decouples

Xiaoyu Hu, William J O'Shaughnessy, Tsebaot G Beraki, Michael L Reese

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Toxoplasma gondii SIR2A Promotes Tachyzoite Invasion via Lysine Deacetylase Activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. The Centrocone Protein SMC_N1 Is Important for the Proliferation ofAnimals : an open access journal from MDPI · 2026
    Article
  4. Article
  5. A divergentResearch square · 2025
    Article
  6. Article
  7. Bumped Kinase Inhibitors Inhibit bothACS infectious diseases · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
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  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiaoyu HuDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
William J O'ShaughnessyDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Tsebaot G BerakiDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Michael L ReeseDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA michael.reese@utsouthwestern.edu.ORCID 0000-0001-9401-9594
The University of Texas Southwestern Medical Center · US

Funding

DIVISION OF CELL &MOLECULAR BIOLOGY TRAINING PROGRAMT32GM008203 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COBB, MELANIE H. · 1987 to 2018
$7.0M
Kinase regulation of trafficking at the Toxoplasma intravacuolar networkR01AI150715 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI REESE, MICHAEL LLOYD · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI150715NIGMS NIH HHS T32 GM008203
6 · The paper itself

Abstract

Mitogen-activated protein kinases (MAPKs) are a conserved family of protein kinases that regulate signal transduction, proliferation, and development throughout eukaryotes. The apicomplexan parasite

Indexed as

Cell CycleCentrosomeDNA ReplicationHumansLife Cycle StagesMitogen-Activated Protein Kinase 1Protozoan ProteinsToxoplasmaToxoplasmosisMitogen-Activated Protein Kinase 1Protozoan Proteinsapicomplexan parasitesapicoplastcell cycle checkpointscentrosomeskinaseMAP kinasesmitochondriaorganellesToxoplasma gondii

Identifiers

PMID33173004
PMCPMC7667025
OpenAlexW3100776277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.